About: Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis

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About: Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis
Creator	Akbari, Hamed Ghahramani, Sulmaz Lankarani, Kamran Nowrouzi-Sohrabi, Peyman Tabrizi, Reza Heydari, Seyed Rezaei, Shahla Ahmadizar, Fariba Akbari, Maryam Kashani, Amin Mohammad, Seyyed Zeidi, Nazanin
Source	Medline; PMC
abstract	BACKGROUND: More severe cases of COVID- 19 are more likely to be hospitalized and around one-fifth, needing ICU admission. Understanding the common laboratory features of COVID-19 in more severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression. This systematic review and meta-analysis aimed to compare the laboratory test findings in severe vs. non-severe confirmed infected cases of COVID-19. METHODS: Electronic databases were systematically searched in PubMed, EMBASE, Scopus, Web of Science, and Google Scholar from the beginning of 2019 to 3rd of March 2020. Heterogeneity across included studies was determined using Cochrane’s Q test and the I(2) statistic. We used the fixed or random-effect models to pool the weighted mean differences (WMDs) or standardized mean differences and 95% confidence intervals (CIs). FINDINGS: Out of a total of 3009 citations, 17 articles (22 studies, 21 from China and one study from Singapore) with 3396 ranging from 12 to1099 patients were included. Our meta-analyses showed a significant decrease in lymphocyte, monocyte, and eosinophil, hemoglobin, platelet, albumin, serum sodium, lymphocyte to C-reactive protein ratio (LCR), leukocyte to C-reactive protein ratio (LeCR), leukocyte to IL-6 ratio (LeIR), and an increase in the neutrophil, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, blood urea nitrogen (BUN), creatinine (Cr), erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), Procalcitonin (PCT), lactate dehydrogenase (LDH), fibrinogen, prothrombin time (PT), D-dimer, glucose level, and neutrophil to lymphocyte ratio (NLR) in the severe group compared with the non-severe group. No significant changes in white blood cells (WBC), Creatine Kinase (CK), troponin I, myoglobin, IL-6 and K between the two groups were observed. INTERPRETATION: This meta-analysis provides evidence for the differentiation of severe cases of COVID-19 based on laboratory test results at the time of ICU admission. Future well-methodologically designed studies from other populations are strongly recommended.
has issue date	2020-08-03(xsd:dateTime)
bibo:doi	10.1186/s40001-020-00432-3
bibo:pmid	32746929
has license	cc-by
sha1sum (hex)	00cce52cfeeae8d529e6b374b8f85eca05d8d41d
schema:url	https://doi.org/10.1186/s40001-020-00432-3
resource representing a document's title	Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis
has PubMed Central identifier	PMC7396942
has PubMed identifier	32746929
schema:publication	Eur J Med Res
resource representing a document's body	covid:00cce52cfeeae8d529e6b374b8f85eca05d8d41d#body_text
is schema:about of	named entity 'COVID-19' named entity 'COVID-19' named entity 'populations' named entity 'CASES' named entity 'HOSPITALIZED' named entity 'FEATURES' named entity 'PATIENTS' named entity 'META-ANALYSIS' named entity 'FEATURES' covid:arg/00cce52cfeeae8d529e6b374b8f85eca05d8d41d named entity 'compare' named entity 'severe' named entity 'infected' named entity 'meta-analysis' named entity 'one-fifth' named entity 'systematic review' named entity 'COVID-19' named entity 'disease progression' named entity 'COVID' named entity 'meta-analysis' named entity 'aspartate aminotransferase' named entity 'computed tomography' named entity 'medical conditions' named entity 'prognosis' named entity 'WMDs' named entity 'COVID' named entity 'WMD' named entity 'myoglobin' named entity 'platelet' named entity 'laboratory tests' named entity 'thrombosis' named entity 'heterogeneity' named entity 'lactate dehydrogenase' named entity 'COVID' named entity 'D-dimer' named entity 'WMD' named entity 'inflammatory' named entity 'hemoglobin' named entity 'PubMed' named entity 'viruses' named entity 'monocyte' named entity 'COVID' named entity 'organ damage' named entity 'COVID' named entity 'liver function tests' named entity 'AST' named entity '2019-nCoV' named entity 'clinical laboratory' named entity 'IL-6' named entity 'COVID' named entity 'serum electrolytes' named entity 'eosinophil' named entity '2019-nCoV' named entity 'IL-6' named entity 'fibrinogen' named entity 'STATA' named entity 'monocytes' named entity 'COVID' named entity 'COVID-19' named entity 'NLR' named entity 'eosinophil' named entity 'Coagulation' named entity 'inflammation' named entity 'lymphocyte' named entity '95% CI' named entity 'thoracic' named entity 'LDH' named entity 'liver function tests' named entity 'LDH' named entity 'Acute Respiratory Distress Syndrome'

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