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About:
Association of HLA class I with severe acute respiratory syndrome coronavirus infection
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An Entity of Type :
schema:ScholarlyArticle
, within Data Space :
wasabi.inria.fr
associated with source
document(s)
Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Association of HLA class I with severe acute respiratory syndrome coronavirus infection
Creator
Chen, Pei-Jan
Huang, Chun-Hsiung
Lin, Ruey-Shiung
Chu, Chen-Chung
Lee, Hui-Lin
Lin, Marie
Lin, Ruey-Yi
Loo, Jun-Hun
Su, Ying-Wen
Tsai, Zen-Uong
Tseng, Hsiang-Kuang
Lim, Ken
Trejaut, Jean
topic
covid:0104f6ceccf92ae8567a0102f89cbb976969a774#this
Source
Medline; PMC
abstract
BACKGROUND: The human leukocyte antigen (HLA) system is widely used as a strategy in the search for the etiology of infectious diseases and autoimmune disorders. During the Taiwan epidemic of severe acute respiratory syndrome (SARS), many health care workers were infected. In an effort to establish a screening program for high risk personal, the distribution of HLA class I and II alleles in case and control groups was examined for the presence of an association to a genetic susceptibly or resistance to SARS coronavirus infection. METHODS: HLA-class I and II allele typing by PCR-SSOP was performed on 37 cases of probable SARS, 28 fever patients excluded later as probable SARS, and 101 non-infected health care workers who were exposed or possibly exposed to SARS coronavirus. An additional control set of 190 normal healthy unrelated Taiwanese was also used in the analysis. RESULTS: Woolf and Haldane Odds ratio (OR) and corrected P-value (Pc) obtained from two tails Fisher exact test were used to show susceptibility of HLA class I or class II alleles with coronavirus infection. At first, when analyzing infected SARS patients and high risk health care workers groups, HLA-B*4601 (OR = 2.08, P = 0.04, Pc = n.s.) and HLA-B*5401 (OR = 5.44, P = 0.02, Pc = n.s.) appeared as the most probable elements that may be favoring SARS coronavirus infection. After selecting only a %22severe cases%22 patient group from the infected %22probable SARS%22 patient group and comparing them with the high risk health care workers group, the severity of SARS was shown to be significantly associated with HLA-B*4601 (P = 0.0008 or Pc = 0.0279). CONCLUSIONS: Densely populated regions with genetically related southern Asian populations appear to be more affected by the spreading of SARS infection. Up until recently, no probable SARS patients were reported among Taiwan indigenous peoples who are genetically distinct from the Taiwanese general population, have no HLA-B* 4601 and have high frequency of HLA-B* 1301. While increase of HLA-B* 4601 allele frequency was observed in the %22Probable SARS infected%22 patient group, a further significant increase of the allele was seen in the %22Severe cases%22 patient group. These results appeared to indicate association of HLA-B* 4601 with the severity of SARS infection in Asian populations. Independent studies are needed to test these results.
has issue date
2003-09-12
(
xsd:dateTime
)
bibo:doi
10.1186/1471-2350-4-9
bibo:pmid
12969506
has license
no-cc
sha1sum (hex)
0104f6ceccf92ae8567a0102f89cbb976969a774
schema:url
https://doi.org/10.1186/1471-2350-4-9
resource representing a document's title
Association of HLA class I with severe acute respiratory syndrome coronavirus infection
has PubMed Central identifier
PMC212558
has PubMed identifier
12969506
schema:publication
BMC Med Genet
resource representing a document's body
covid:0104f6ceccf92ae8567a0102f89cbb976969a774#body_text
is
http://vocab.deri.ie/void#inDataset
of
proxy:http/ns.inria.fr/covid19/0104f6ceccf92ae8567a0102f89cbb976969a774
is
schema:about
of
named entity 'infected'
named entity 'DISTRIBUTION'
named entity 'AUTOIMMUNE DISORDERS'
named entity 'SEVERE ACUTE RESPIRATORY SYNDROME'
named entity 'TAIWAN'
named entity 'GENETIC'
named entity 'RESISTANCE TO'
named entity 'ASSOCIATION'
named entity 'EPIDEMIC'
named entity 'HIGH RISK'
named entity 'ALLELES'
named entity 'CORONAVIRUS INFECTION'
named entity 'SEARCH'
named entity 'HLA CLASS I'
named entity 'SCREENING'
named entity 'STRATEGY'
named entity 'HUMAN LEUKOCYTE ANTIGEN'
named entity 'CORONAVIRUS INFECTION'
named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS'
named entity 'MEDICAL GENETICS'
named entity 'HLA CLASS I'
named entity 'USED'
named entity 'ASSOCIATION'
named entity 'BMC'
named entity 'SARS CORONAVIRUS'
named entity 'PRESENCE OF'
named entity 'HEALTH CARE'
named entity 'INFECTED'
named entity 'CONTROL GROUPS'
named entity 'WORKERS'
named entity 'CASE'
named entity 'INFECTIOUS DISEASES'
named entity 'PERSONAL'
named entity 'ETIOLOGY'
named entity 'PROGRAM'
named entity 'EFFORT'
named entity 'SYSTEM'
named entity 'ESTABLISH'
named entity 'EXAMINED FOR'
covid:arg/0104f6ceccf92ae8567a0102f89cbb976969a774
named entity 'presence'
named entity 'infectious diseases'
named entity 'epidemic'
named entity 'HLA'
named entity 'HLA'
named entity 'HLA'
named entity 'SARS'
named entity 'SARS'
named entity 'HLA-B13'
named entity 'human coronavirus OC43'
named entity 'type I error'
named entity 'Hilden'
named entity 'B46'
named entity 'epidemic'
named entity 'HLA'
named entity 'health care workers'
named entity 'AST'
named entity 'clinical outcome'
named entity 'SARS coronavirus'
named entity 'Beijing'
named entity 'IgG'
named entity 'Serum samples'
named entity 'SARS'
named entity 'SARS'
named entity 'Odds ratios'
named entity 'Thai Chinese'
named entity 'HLA'
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