About: Feature Selection Methods for Identifying Genetic Determinants of Host Species in RNA Viruses

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Feature Selection Methods for Identifying Genetic Determinants of Host Species in RNA Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Feature Selection Methods for Identifying Genetic Determinants of Host Species in RNA Viruses
Creator	Ferguson, N Aguas, R
topic	covid:01110a24b6ce133ae80d21a36c7994e364ba296c#this
Source	Medline; PMC
abstract	Despite environmental, social and ecological dependencies, emergence of zoonotic viruses in human populations is clearly also affected by genetic factors which determine cross-species transmission potential. RNA viruses pose an interesting case study given their mutation rates are orders of magnitude higher than any other pathogen – as reflected by the recent emergence of SARS and Influenza for example. Here, we show how feature selection techniques can be used to reliably classify viral sequences by host species, and to identify the crucial minority of host-specific sites in pathogen genomic data. The variability in alleles at those sites can be translated into prediction probabilities that a particular pathogen isolate is adapted to a given host. We illustrate the power of these methods by: 1) identifying the sites explaining SARS coronavirus differences between human, bat and palm civet samples; 2) showing how cross species jumps of rabies virus among bat populations can be readily identified; and 3) de novo identification of likely functional influenza host discriminant markers.
has issue date	2013-10-10(xsd:dateTime)
bibo:doi	10.1371/journal.pcbi.1003254
bibo:pmid	24130470
has license	cc-by
sha1sum (hex)	01110a24b6ce133ae80d21a36c7994e364ba296c
schema:url	https://doi.org/10.1371/journal.pcbi.1003254
resource representing a document's title	Feature Selection Methods for Identifying Genetic Determinants of Host Species in RNA Viruses
has PubMed Central identifier	PMC3794897
has PubMed identifier	24130470
schema:publication	PLoS Comput Biol
resource representing a document's body	covid:01110a24b6ce133ae80d21a36c7994e364ba296c#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/01110a24b6ce133ae80d21a36c7994e364ba296c
is schema:about of	named entity 'FEATURE SELECTION' named entity 'isolate' named entity 'sites' named entity 'reflected' named entity 'translated' named entity 'orders' named entity 'TRANSLATED' named entity 'DE NOVO' named entity 'GIVEN' named entity 'POPULATIONS' named entity 'PATHOGEN' named entity 'MUTATION RATES' named entity 'ENVIRONMENTAL' named entity 'ALLELES' named entity 'JUMPS' named entity 'TRANSMISSION' named entity 'MAGNITUDE' named entity 'SEQUENCES' named entity 'REFLECTED' named entity 'EXAMPLE' named entity 'VIRUSES' named entity 'PROBABILITIES' named entity 'MINORITY' named entity 'DEPENDENCIES' named entity 'POSE' named entity 'SARS' named entity 'SOCIAL' named entity 'HUMAN' named entity 'PREDICTION' named entity 'PALM' named entity 'BAT' named entity 'SITES' named entity 'FUNCTIONAL' named entity 'HERE' named entity 'RNA VIRUSES' named entity 'VIRAL' named entity 'GENOMIC DATA' named entity 'IDENTIFIED' named entity 'EMERGENCE' named entity 'ZOONOTIC' named entity 'ISOLATE' named entity 'CROSS' named entity 'HOW' named entity 'ECOLOGICAL' named entity 'LIKELY' named entity 'ORDERS' named entity 'TO IDENTIFY' named entity 'POWER' named entity 'IDENTIFYING' named entity 'DETERMINANTS' named entity 'HIGHER' named entity 'METHODS' named entity 'GENETIC' named entity 'HOST SPECIES' named entity 'THEIR' named entity 'RABIES VIRUS' named entity 'THESE' named entity 'GENETIC FACTORS' named entity 'PARTICULAR' named entity 'POTENTIAL' named entity 'INFLUENZA' named entity 'USED' named entity 'MARKERS' named entity 'CASE STUDY' named entity 'TECHNIQUES' named entity 'SPECIES' named entity 'HOST SPECIES' named entity 'RECENT' named entity 'IDENTIFICATION' named entity 'SPECIFIC' named entity 'HOST' named entity 'METHODS' named entity 'IDENTIFYING' named entity 'AFFECTED' named entity 'ADAPTED' named entity 'RNA VIRUSES' named entity 'VARIABILITY' named entity 'CIVET'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software