About: Which sample type is better for Xpert MTB/RIF to diagnose adult and pediatric pulmonary tuberculosis?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Which sample type is better for Xpert MTB/RIF to diagnose adult and pediatric pulmonary tuberculosis?
Creator	Zhou, Jian Ying, Binwu Wu, Kang Cheng, Yuhui Chong, Weelic Fang, Teng Fu, Tianbo Lyu, Mengyuan
Source	PMC
abstract	Objective: This review aimed to identify proper respiratory-related sample types for adult and pediatric pulmonary tuberculosis (PTB), respectively, by comparing performance of Xpert MTB/RIF when using bronchoalveolar lavage (BAL), induced sputum (IS), expectorated sputum (ES), nasopharyngeal aspirates (NPAs), and gastric aspiration (GA) as sample. Methods: Articles were searched in Web of Science, PubMed, and Ovid from inception up to 29 June 2020. Pooled sensitivity and specificity were calculated, each with a 95% confidence interval (CI). Quality assessment and heterogeneity evaluation across included studies were performed. Results: A total of 50 articles were included. The respective sensitivity and specificity were 87% (95% CI: 0.84–0.89), 91% (95% CI: 0.90–0.92) and 95% (95% CI: 0.93–0.97) in the adult BAL group; 90% (95% CI: 0.88–0.91), 98% (95% CI: 0.97–0.98) and 97% (95% CI: 0.95–0.99) in the adult ES group; 86% (95% CI: 0.84–0.89) and 97% (95% CI: 0.96–0.98) in the adult IS group. Xpert MTB/RIF showed the sensitivity and specificity of 14% (95% CI: 0.10–0.19) and 99% (95% CI: 0.97–1.00) in the pediatric ES group; 80% (95% CI: 0.72–0.87) and 94% (95% CI: 0.92–0.95) in the pediatric GA group; 67% (95% CI: 0.62–0.72) and 99% (95% CI: 0.98–0.99) in the pediatric IS group; and 54% (95% CI: 0.43–0.64) and 99% (95% CI: 0.97–0.99) in the pediatric NPA group. The heterogeneity across included studies was deemed acceptable. Conclusion: Considering diagnostic accuracy, cost and sampling process, ES was a better choice than other sample types for diagnosing adult PTB, especially HIV-associated PTB. GA might be more suitable than other sample types for diagnosing pediatric PTB. The actual choice of sample types should also consider the needs of specific situations.
has issue date	2020-08-04(xsd:dateTime)
bibo:doi	10.1042/bsr20200308
bibo:pmid	32701147
has license	cc-by
sha1sum (hex)	011d1548536b067db6422e7fcf9d5bfd87bb9250
schema:url	https://doi.org/10.1042/bsr20200308
resource representing a document's title	Which sample type is better for Xpert MTB/RIF to diagnose adult and pediatric pulmonary tuberculosis?
has PubMed Central identifier	PMC7403955
has PubMed identifier	32701147
schema:publication	Biosci Rep
resource representing a document's body	covid:011d1548536b067db6422e7fcf9d5bfd87bb9250#body_text
is schema:about of	named entity 'confidence interval' named entity 'group' named entity 'adult' named entity 'group' named entity 'articles' named entity 'PULMONARY TUBERCULOSIS' named entity 'EXPECTORATED' named entity 'REVIEW' named entity 'PTB' named entity 'adult' named entity 'PTB' named entity 'performance' named entity 'bronchoalveolar lavage' named entity 'induced' named entity '95% CI' named entity 'Ovid' named entity 'specificity' named entity 'gastric' named entity 'inception' named entity 'sputum' named entity '95% CI' named entity '95%' named entity '95% CI' named entity 'sensitivity and specificity' named entity 'Web of Science' named entity '95% CI' named entity 'HIV' named entity 'pediatric' named entity '95% CI' named entity 'sensitivity and specificity' named entity 'pulmonary tuberculosis' named entity 'pediatric' named entity 'PCR' named entity 'Xpert MTB/RIF' named entity 'probability' named entity 'aspirates' named entity 'lung diseases' named entity 'clinical practice' named entity 'Xpert MTB/RIF' named entity 'nasopharyngeal' named entity 'Mycobacterium tuberculosis' named entity 'HIV-negative' named entity 'sputum' named entity 'lesion' named entity 'Barcelona' named entity 'Xpert MTB/RIF' named entity 'sputum' named entity 'sputum' named entity 'HIV-positive' named entity 'pediatric' named entity '3/14' named entity 'mycobacterium tuberculosis' named entity 'sputum' named entity 'Spearman correlation' named entity 'Microsoft Excel' named entity 'bronchoalveolar lavage fluid' named entity 'World Health Organization' named entity 'lung infection' named entity 'microbiology' named entity 'Xpert MTB/RIF' named entity 'Spain' named entity 'diagnostic tools' named entity 'BALF' named entity 'meta-analysis' named entity 'pediatric' named entity 'clinical trials' named entity 'diagnostic test' named entity 'Xpert MTB/RIF' named entity 'diagnostic accuracy' named entity 'early diagnosis' named entity 'infection' named entity 'sputum' named entity 'Xpert MTB/RIF' named entity 'interferon-γ release assay'

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