About: Identify clinical factors related to Mycoplasma pneumoniae pneumonia with hypoxia in children

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identify clinical factors related to Mycoplasma pneumoniae pneumonia with hypoxia in children
Creator	Guo, Wei Tian, Jiao Cai, Chunquan Ling, Yaoyao Xu, Yongsheng Zhang, Tongqiang Zhu, Zhenli
Source	PMC
abstract	BACKGROUND: To analyze the clinical characteristics of Mycoplasma pneumoniae pneumonia with hypoxia in children, and identify the associated risk factors of hypoxia in MPP. METHODS: A retrospective case-control study was performed on 345 children with Mycoplasma pneumoniae pneumonia (MPP) admitted to our hospital wards from January 2017 to June 2019. They were divided into three groups, namely MPP with hypoxia, refractory Mycoplasma pneumoniae pneumonia (RMPP), and general Mycoplasma pneumoniae pneumonia (GMPP). The clinical features, laboratory findings, imaging, and management were collected and compared in the three groups. RESULTS: The MPP with hypoxia patients (n = 69) had longer disease duration, a higher extra-pulmonary complications rate, and more severe radiological abnormalities (P < 0.05). They also needed more complicated treatments (P < 0.05). Meanwhile, the levels of white blood cell count (WBC), C-reactive protein (CRP), lactic dehydrogenase (LDH), interleukin (IL)-6, ferritin, D-dimer, fibrinogen (FG), alanine aminotransferase (ALT) and the percentage of neutrophils in the MPP with hypoxia group were significantly higher than those in the RMPP group and the GMPP group (P < 0.05). In ROC curve analysis, the percentage of neutrophils, WBC, CRP, LDH, IL-6, ferritin, D-dimer, and ALT were contributed to identify the MPP with hypoxia patients. Multivariate logistic regression analysis revealed that ferritin> 174.15 ng/mL, IL-6 > 25.475 pg/ml, and pleural effusion were significantly associated with the incidence of hypoxia in MPP (P < 0.01). CONCLUSION: MPP with hypoxia patients presented more serious clinical manifestations. Ferritin> 174.15 ng/mL, IL-6 > 25.475 pg/ml and pleural effusion were related risk factors for hypoxia in MPP.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1186/s12879-020-05270-6
has license	cc-by
sha1sum (hex)	013d4e86b5818d68f587445e98aa6b0371be715f
schema:url	https://doi.org/10.1186/s12879-020-05270-6
resource representing a document's title	Identify clinical factors related to Mycoplasma pneumoniae pneumonia with hypoxia in children
has PubMed Central identifier	PMC7374650
schema:publication	BMC Infect Dis
resource representing a document's body	covid:013d4e86b5818d68f587445e98aa6b0371be715f#body_text
is schema:about of	named entity 'collected' named entity 'pneumonia' named entity 'COLLECTED' named entity 'CLINICAL FEATURES' named entity 'METHODS' named entity 'pneumonia' named entity 'groups' named entity 'identify' named entity 'compared' named entity 'refractory' named entity 'hypoxia' named entity 'hypoxia' named entity 'pneumonia' named entity 'Mycoplasma pneumoniae' named entity 'Mycoplasma pneumoniae' named entity 'risk factors' named entity 'pneumonia' named entity 'hypoxia' named entity 'pneumonia' named entity 'hypoxia' named entity 'area under the curve' named entity 'diagnostic criteria' named entity 'randomly selected' named entity 'early diagnosis' named entity 'diagnostic criteria' named entity 'oxygen saturation' named entity 'interleukin (IL)-6' named entity 'infection' named entity 'hypoxia' named entity 'sensitivity and specificity' named entity 'D-dimer' named entity 'hypoxia' named entity 'hypoxia' named entity 'D-dimer' named entity 'infection' named entity 'pathogen' named entity 'Mycoplasma pneumoniae' named entity 'Ferritin' named entity 'China' named entity 'Chest radiography' named entity 'nasopharyngeal aspirate' named entity 'macrolides' named entity 'hypoxia' named entity 'aspartate aminotransferase' named entity 'inflammatory reaction' named entity 'ferritin' named entity 'lung' named entity 'alanine aminotransferase' named entity 'hypoxia' named entity 'complete blood count' named entity '3.70' named entity 'pleural effusion' named entity 'ROC analysis' named entity 'hypoxia' named entity 'signs and symptoms' named entity 'hypoxia' named entity 'CT scans' named entity 'logistic regression' named entity 'ng/mL' named entity 'acute respiratory distress syndrome' named entity 'immune response' named entity 'hypoxia' named entity 'hypoxia' named entity 'CT scan' named entity 'WBC' named entity 'D-dimer' named entity 'ROC' named entity '0.45' named entity 'reverse transcriptase' named entity '0.01' named entity 'antibody' named entity 'fulminant' named entity 'LDH' named entity 'atelectasis' named entity 'hypoxia' named entity 'ng/mL' named entity 'inflammatory marker'

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