About: Gut microbiota in neonates with congenital gastrointestinal surgical conditions: a prospective study

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About: Gut microbiota in neonates with congenital gastrointestinal surgical conditions: a prospective study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gut microbiota in neonates with congenital gastrointestinal surgical conditions: a prospective study
Creator	Keil, Anthony Chen, Liwei Conway, Patricia Esvaran, Meera Gollow, Ian Patole, Sanjay Rao, Shripada Simmer, Karen Wemheuer, Bernd
Source	PMC
abstract	BACKGROUND: There is limited information on gut microbiota of neonates with congenital gastrointestinal surgical conditions (CGISCs) available. METHODS: This study compared stool microbiota and short-chain fatty acids (SCFAs) of 37 term infants with CGISCs with 36 term healthy infants (HIs). Two stool samples were collected from each infant: as soon as possible after birth (week 1) and 10–14 days of life (week 2). RESULTS: Bacterial richness and alpha diversity were comparable between CGISCs and HIs at week 1 and week 2 (all p > 0.05). Beta diversity analysis revealed that at week 1, CGISCs had similar community structures to HIs (p = 0.415). However, by week 2, community structures of CGISCs were significantly different from HIs (p = 0.003). At week 1, there were no significant differences in the relative abundances of genera Bifidobacterium and Bacteroides between CGISCs and HIs. At week 2, the relative abundance of Bifidobacterium was significantly lower in CGISCs (mean percentage 7.21 ± 13.49 vs. 28.96 ± 19.6; p = 0.002). Bacteroides were also less abundant in the CGISC group (mean percentage 0.12 ± 0.49 vs. 6.59 ± 8.62; p = 0.039). Relative abundance of genera Pseudomonas and Escherichia–Shigella were higher in CGISCs. At week 2, stool concentrations of all SCFAs were lower in CGISCs (all p < 0.001). CONCLUSIONS: During hospitalization, neonates with CGISCs develop gut dysbiosis and deficiency of SCFAs. IMPACT: During hospitalisation, neonates with congenital gastrointestinal surgical conditions develop gut dysbiosis with deficiency of Bifidobacteria and Bacteroides and increased abundance of Escherichia-Shigella and Pseudomonas. They also have low levels of short chain fatty acids in their stools compared to healthy infants. This is the first study evaluating the gut microbiota using 16S ribosomal RNA sequencing methods and stool short chain fatty acids in neonates with congenital gastrointestinal surgical conditions and comparing them to healthy infants. The findings of this study will pave the way for randomised trials of bifidobacterial supplementation in neonates with congenital gastrointestinal surgical conditions.
has issue date	2020-03-16(xsd:dateTime)
bibo:doi	10.1038/s41390-020-0824-7
bibo:pmid	32179871
has license	no-cc
sha1sum (hex)	01742fce17ef43a15035e0d0db8d8e6c6427a622
schema:url	https://doi.org/10.1038/s41390-020-0824-7
resource representing a document's title	Gut microbiota in neonates with congenital gastrointestinal surgical conditions: a prospective study
has PubMed Central identifier	PMC7223116
has PubMed identifier	32179871
schema:publication	Pediatr Res
resource representing a document's body	covid:01742fce17ef43a15035e0d0db8d8e6c6427a622#body_text
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