About: Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong
Creator	Yuen, Kwok-Yung Wu, Alan Yip, Cyril Chow, Wang-Ngai Lau, Susanna To, Kelvin Woo, Patrick Zhao, Su-Hui
source	Medline; PMC
abstract	Despite the recent emergence of enterovirus D68 (EV-D68), its clinical impact on adult population is less well defined. To better define the epidemiology of EV-D68, 6,800 nasopharyngeal aspirates (NPAs) from 2010–2014 were subject to EV-D68 detection by RT-PCR and sequencing of 5′UTR and partial VP1. EV-D68 was detected in 30 (0.44%) NPAs from 22 children and 8 adults/elderlies. Sixteen patients (including five elderly) (53%) had pneumonia and 13 (43%) patients were complicated by small airway disease exacerbation. Phylogenetic analysis of VP1, 2C and 3D regions showed four distinct lineages of EV-D68, clade A1, A2, B1 and B3, with adults/elderlies exclusively infected by clade A2. The potentially new clade, B3, has emerged in 2014, while strains closely related to recently emerged B1 strains in the United States were also detected as early as 2011 in Hong Kong. The four lineages possessed distinct aa sequence patterns in BC and DE loops. Amino acid residues 97 and 140, within BC and DE-surface loops of VP1 respectively, were under potential positive selection. EV-D68 infections in Hong Kong usually peak in spring/summer, though with a delayed autumn/winter peak in 2011. This report suggests that EV-D68 may cause severe respiratory illness in adults/elderlies with underlying co-morbidities.
has issue date	2016-04-28(xsd:dateTime)
bibo:doi	10.1038/srep25147
bibo:pmid	27121085
has license	cc-by
sha1sum (hex)	0180abece22ace6548f4601591c98059808d0509
schema:url	https://doi.org/10.1038/srep25147
resource representing a document's title	Enterovirus D68 Infections Associated with Severe Respiratory Illness in Elderly Patients and Emergence of a Novel Clade in Hong Kong
has PubMed Central identifier	PMC4848506
has PubMed identifier	27121085
schema:publication	Sci Rep
resource representing a document's body	covid:0180abece22ace6548f4601591c98059808d0509#body_text
is schema:about of	named entity 'NOVEL' named entity 'NPAs' named entity 'winter' named entity 'RT-PCR' named entity 'severe' named entity 'ADULTS' named entity 'IMPACT' named entity 'SUBJECT' named entity 'WELL DEFINED' named entity 'ITS' named entity 'RECENT' named entity 'CAUSE' named entity 'NEW' named entity 'AMINO ACID' named entity 'POTENTIAL' named entity 'ASPIRATES' named entity 'D68' named entity 'INFECTIONS' named entity 'POSSESSED' named entity 'POSITIVE SELECTION' named entity 'NASOPHARYNGEAL' named entity 'BETTER' named entity 'POPULATION' named entity '140' named entity 'UNDERLYING' named entity 'DISTINCT' named entity 'EARLY' named entity 'INFECTED' named entity 'EMERGENCE' named entity 'SEQUENCING' named entity 'CO-MORBIDITIES' named entity '80%' named entity '2011' named entity 'CLADE' named entity 'PATIENTS' named entity 'HONG KONG' named entity 'DELAYED' named entity 'PNEUMONIA' named entity 'PEAK' named entity 'COMPLICATED BY' named entity 'CHILDREN' named entity 'ENTEROVIRUS D68' named entity 'ASSOCIATED WITH' named entity 'HONG KONG' named entity 'RESPIRATORY ILLNESS' named entity 'SEVERE' named entity 'ADULT' named entity 'ENTEROVIRUS D68' named entity 'LOOPS' named entity 'RELATED' named entity 'PHYLOGENETIC ANALYSIS' named entity 'RECENTLY' named entity 'DETECTION' named entity 'DETECTED' named entity 'AUTUMN' named entity 'SEVERE' named entity 'PATTERNS' named entity 'RT-PCR' named entity 'INFECTIONS' named entity 'RESPIRATORY ILLNESS' named entity 'SIXTEEN' named entity 'SPRING' named entity 'SURFACE' named entity 'VP1' named entity 'USUALLY' named entity 'ELDERLY' named entity 'CLADE' named entity 'EMERGENCE' named entity 'ELDERLY PATIENTS' named entity 'SMALL AIRWAY DISEASE' named entity 'UNITED STATES' named entity 'AA SEQUENCE' named entity 'EPIDEMIOLOGY' named entity 'STRAINS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software