About: The effect of diatomaceous earth in live, attenuated infectious bronchitis vaccine, immune responses, and protection against challenge

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About: The effect of diatomaceous earth in live, attenuated infectious bronchitis vaccine, immune responses, and protection against challenge Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The effect of diatomaceous earth in live, attenuated infectious bronchitis vaccine, immune responses, and protection against challenge
Creator	Hauck, Rüdiger Nazmi, Ali Corbeil, Lynette Gallardo, Rodrigo
Source	Elsevier; Medline; PMC
abstract	Abstract Live virus vaccines are commonly used in poultry production, particularly in broilers. Massive application and generation of a protective local mucosal and humoral immunity with no adverse effects is the main goal for this strategy. Live virus vaccines can be improved by adding adjuvants to boost mucosal innate and adaptive responses. In a previous study we showed that diatomaceous earth (DE) can be used as adjuvant in inactivated vaccines. The aim of this study was to test DE as adjuvant in an Ark-DPI live infectious bronchitis virus (IBV) vaccine after ocular or spray application. Titrating the virus alone or after addition of DE showed that DE had no detrimental effect on the vaccine virus. However, adding DE to the vaccine did not induce higher IgG titers in the serum and IgA titers in tears. It also did not affect the frequency of CD4+ T cells, CD8+ T cells and monocytes/macrophages in the blood and the spleen determined by flow cytometry. In addition, protection generated against IBV homologous challenges, measured by viral load in tears, respiratory signs and histopathology in tracheas, did not vary when DE was present in the vaccine formulation. Finally, we confirmed through our observations that Ark vaccines administered by hatchery spray cabinet elicit weaker immune responses and protection against an IBV homologous challenge compared to the same vaccine delivered via ocular route.
has issue date	2017-08-01(xsd:dateTime)
bibo:doi	10.3382/ps/pex093
bibo:pmid	28419351
has license	els-covid
sha1sum (hex)	0185df64da339e8d1b822db72fee79a25edeb759
schema:url	https://doi.org/10.3382/ps/pex093
resource representing a document's title	The effect of diatomaceous earth in live, attenuated infectious bronchitis vaccine, immune responses, and protection against challenge
has PubMed Central identifier	PMC7107116
has PubMed identifier	28419351
schema:publication	Poultry Science
resource representing a document's body	covid:0185df64da339e8d1b822db72fee79a25edeb759#body_text
is schema:about of	named entity 'vaccines' named entity 'generated' named entity 'vaccine' named entity 'adjuvants' named entity 'homologous' named entity 'homologous' named entity 'tears' named entity 'vaccine' named entity 'live, attenuated' named entity 'CHALLENGE' covid:arg/0185df64da339e8d1b822db72fee79a25edeb759 named entity 'OCULAR' named entity 'IMMUNE RESPONSES' named entity 'BRONCHITIS VACCINE' named entity 'CABINET' named entity 'T CELLS' named entity 'CHALLENGE' named entity 'FORMULATION' named entity 'DETERMINED BY' named entity 'FREQUENCY' named entity 'AIM' named entity 'PREVIOUS' named entity 'EFFECT' named entity 'GENERATION' named entity 'HATCHERY' named entity 'TEARS' named entity 'APPLICATION' named entity 'IGA' named entity 'CD8' named entity 'RESPONSES' named entity 'ADVERSE EFFECTS' named entity 'DELIVERED' named entity 'CONFIRMED' named entity 'HOMOLOGOUS' named entity 'MAIN' named entity 'LIVE' named entity 'TO TEST' named entity 'BOOST' named entity 'VACCINES' named entity 'DID' named entity 'VIRAL LOAD' named entity 'DIATOMACEOUS EARTH' named entity 'INDUCE' named entity 'PROTECTION' named entity 'ADDITION' named entity 'ATTENUATED' named entity 'LIVE' named entity 'RESPIRATORY' named entity 'HISTOPATHOLOGY' named entity 'POULTRY PRODUCTION' named entity 'ADJUVANT' named entity 'DIATOMACEOUS EARTH' named entity 'EFFECT' named entity 'INFECTIOUS BRONCHITIS' named entity 'IMMUNE RESPONSES' named entity 'CD4' named entity 'OCULAR ROUTE' named entity 'FLOW CYTOMETRY' named entity 'ADDING' named entity 'MEASURED' named entity 'INACTIVATED VACCINES' named entity 'MUCOSAL' named entity 'ADAPTIVE' named entity 'PROTECTION' named entity 'AFFECT' named entity 'SPRAY' named entity 'CHALLENGES' named entity 'LOCAL' named entity 'IMPROVED BY' named entity 'TRACHEAS' named entity 'ARK' named entity 'SPLEEN' named entity 'MONOCYTES' named entity 'MASSIVE' named entity 'ADMINISTERED' named entity 'STRATEGY' named entity 'SIGNS' named entity 'HUMORAL IMMUNITY'

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