About: Unique Epitopes Recognized by Antibodies Induced in Chikungunya Virus-Infected Non-Human Primates: Implications for the Study of Immunopathology and Vaccine Development

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About: Unique Epitopes Recognized by Antibodies Induced in Chikungunya Virus-Infected Non-Human Primates: Implications for the Study of Immunopathology and Vaccine Development Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Unique Epitopes Recognized by Antibodies Induced in Chikungunya Virus-Infected Non-Human Primates: Implications for the Study of Immunopathology and Vaccine Development
Creator	Lu, Shan Merits, Andres Kam, Yiu-Wing Le Grand, Roger Roques, Pierre Simarmata, Diane Tolou, Hugues Ng, Lisa Lee, Wendy
Source	PMC
abstract	Chikungunya virus (CHIKV) is an Alphavirus that causes chronic and incapacitating arthralgia in humans. Although patient cohort studies have shown the production of CHIKV specific antibodies, the fine specificity of the antibody response against CHIKV is not completely defined. The macaque model of CHIKV infection was established due to limitations of clinical specimens. More importantly, its close relation to humans will allow the study of chronic infection and further identify important CHIKV targets. In this study, serum samples from CHIKV-infected macaques collected at different time-points post infection were used to characterize the antibody production pattern and kinetics. Results revealed that anti-CHIKV antibodies were neutralizing and the E2 glycoprotein, Capsid, nsP1, nsP3 and nsP4 proteins were targets of the anti-CHIKV antibody response in macaques. Furthermore, linear B-cell epitopes recognized by these anti-CHIKV antibodies were identified, and mapped to their structural localization. This characterizes the specificity of anti-CHIKV antibody response in macaques and further demonstrates the importance of the different regions in CHIKV-encoded proteins in the adaptive immune response. Information from this study provides critical knowledge that will aid in the understanding of CHIKV infection and immunity, vaccine design, and pre-clinical efficacy studies.
has issue date	2014-04-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0095647
bibo:pmid	24755730
has license	cc-by
sha1sum (hex)	018b618ea132d47ffb43b003a6c78cb9eeadc017
schema:url	https://doi.org/10.1371/journal.pone.0095647
resource representing a document's title	Unique Epitopes Recognized by Antibodies Induced in Chikungunya Virus-Infected Non-Human Primates: Implications for the Study of Immunopathology and Vaccine Development
has PubMed Central identifier	PMC3995782
has PubMed identifier	24755730
schema:publication	PLoS One
resource representing a document's body	covid:018b618ea132d47ffb43b003a6c78cb9eeadc017#body_text
is schema:about of	named entity 'UNIQUE' named entity 'CHIKV' named entity 'CHIKV' named entity 'structural' named entity 'Alphavirus' named entity 'infection' named entity 'Antibodies' named entity 'Vaccine' named entity 'VACCINE DEVELOPMENT' named entity 'INDUCED' named entity 'PRIMATES' named entity 'HUMAN' named entity 'TARGETS' named entity 'CRITICAL' named entity 'STUDIES' named entity 'SERUM' named entity 'ALPHAVIRUS' named entity 'LOCALIZATION' named entity 'RELATION' named entity 'DIFFERENT' named entity 'UNDERSTANDING' named entity 'POINTS' named entity 'STRUCTURAL' named entity 'COLLECTED' named entity 'INFECTION' named entity 'NSP1' named entity 'AID' named entity 'EPITOPES' named entity 'TIME' named entity 'GLYCOPROTEIN' named entity 'DEFINED' named entity 'B-CELL' named entity 'CLINICAL EFFICACY' named entity 'ITS' named entity 'CHARACTERIZES' named entity 'PATIENT' named entity 'STUDY' named entity 'ARTHRALGIA' named entity 'NSP3' named entity 'CLINICAL' named entity 'IDENTIFIED' named entity 'CAUSES' named entity 'INFECTED' named entity 'ANTIBODY RESPONSE' named entity 'DUE TO' named entity 'USED' named entity 'RESULTS' named entity 'INFORMATION' named entity 'MODEL OF' named entity 'HAVE' named entity 'POST' named entity 'PRE-CLINICAL' named entity 'CHIKV INFECTION' named entity 'THEIR' named entity 'PATTERN' named entity 'REGIONS' covid:arg/018b618ea132d47ffb43b003a6c78cb9eeadc017 named entity 'INFECTED' named entity 'CHRONIC' named entity 'VACCINE DESIGN' named entity 'CHIKUNGUNYA VIRUS' named entity 'ANTIBODIES' named entity 'STUDY' named entity 'REVEALED' named entity 'PROVIDES' named entity 'CAPSID' named entity 'IMMUNOPATHOLOGY' named entity 'EPITOPES' named entity 'SAMPLES' named entity 'MACAQUE' named entity 'MACAQUES' named entity 'KINETICS' named entity 'IMPORTANT'

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