About: TNF-α priming effect on polymorphonuclear leukocyte reactive oxygen species generation and adhesion molecule expression in hemodialyzed patients

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About: TNF-α priming effect on polymorphonuclear leukocyte reactive oxygen species generation and adhesion molecule expression in hemodialyzed patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TNF-α priming effect on polymorphonuclear leukocyte reactive oxygen species generation and adhesion molecule expression in hemodialyzed patients
Creator	Banach, Maciej Baj, Zbigniew Ciałkowska, Aleksandra Markuszewski, Leszek Pasnik, Jarosław Rysz, Jacek Rysz, − Stolarek, Robert
Source	Medline; PMC
abstract	INTRODUCTION: The study aimed to assess reactive oxygen species generation and the expressions of some surface antigens on polymorphonuclear leukocytes (PMNs) in patients on regular hemodialysis (HD) treatment. MATERIALS AND METHODS: The respiratory burst of PMNs was determined with luminol-dependent chemiluminescence (CL) in resting cells and following N-formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol 12-myristate 13-acetate (PMA), or opsonized zymosan (OZ) stimulation and expressed in arbitrary CL units times assay-time (aU × min). The expressions of CD11b/CD18, CD10, and CD13 receptors were determined with flow cytometry. RESULTS: Basal PMN CL was increased in HD patients to up to 1285 ± 129 aU × min compared with 895 ± 88 aU × min in healthy controls (p < 0.05). The CL of unprimed PMNs increased after fMLP stimulation from 3085 ± 746 to 4529 ± 808 aU × min, and after OZ stimulation from 12945 ± 1296 to 14678 ± 1355 aU × min. PMA-stimulated CL of PMNs was similar to control values. The oxidative burst in PMNs from HD patients and healthy controls was similar in response to TNF-α alone. The CL of TNF-α-primed PMNs in HD patients was significantly lower than CL measured in healthy controls (p < 0.05). The expressions of CD10 and CD13 metalloproteinase receptors were also increased (p < 0.05). Although CD11b expression was significantly increased at rest and after fMLP stimulation, the expression of another β-integrin heterodimer compound, CD18, was not increased. CONCLUSIONS: These results provide evidence that TNF-α priming of PMNs is down-regulated in HD patients despite constitutive up-regulation of resting cytotoxicity and enhanced expression of adhesion and metalloproteinase receptors.
has issue date	2006-05-31(xsd:dateTime)
bibo:doi	10.1007/s00005-006-0023-1
bibo:pmid	16736108
has license	no-cc
sha1sum (hex)	01d94776175a7a6c3f6ef25ae63f00f424b4c242
schema:url	https://doi.org/10.1007/s00005-006-0023-1
resource representing a document's title	TNF-α priming effect on polymorphonuclear leukocyte reactive oxygen species generation and adhesion molecule expression in hemodialyzed patients
has PubMed Central identifier	PMC7079744
has PubMed identifier	16736108
schema:publication	Arch Immunol Ther Exp (Warsz)
resource representing a document's body	covid:01d94776175a7a6c3f6ef25ae63f00f424b4c242#body_text
is schema:about of	named entity 'TNF-α' named entity 'expression' named entity 'patients' named entity 'provide' named entity 'stimulation' named entity 'patients' named entity 'compound' named entity 'patients' named entity 'polymorphonuclear leukocyte' named entity 'CD11B' named entity 'UP TO' named entity 'TIMES' named entity 'FOLLOWING' named entity 'DEPENDENT' named entity 'ASSAY' covid:arg/01d94776175a7a6c3f6ef25ae63f00f424b4c242 named entity 'CD18' named entity 'units' named entity 'PMN' named entity 'Materials' named entity 'myristate' named entity 'patients' named entity 'PMNs' named entity 'opsonized' named entity 'flow cytometry' named entity 'resting' named entity 'fMLP' named entity 'controls' named entity 'up-regulation' named entity 'rest' named entity 'adhesion molecule' named entity 'assay' named entity 'flow cytometry' named entity 'up-regulation' named entity 'CD13' named entity 'PMNs' named entity 'opsonized' named entity 'zymosan' named entity 'CD11b' named entity 'adhesion molecule' named entity 'TNF-α' named entity 'CD13' named entity 'TNF-α' named entity 'regulated expressions' named entity 'Germany' named entity 'dialyzed' named entity 'CD11b' named entity 'TNF-α' named entity 'superoxide dismutase' named entity 'upregulated' named entity 'TNF-α' named entity 'neutral endopeptidase' named entity 'PMNs' named entity 'Denmark' named entity 'acetate' named entity 'TNF-α' named entity 'ROS' named entity 'CD18' named entity 'oxidase' named entity 'MHC II' named entity 'chronic renal failure' named entity 'PBS' named entity 'up-regulation' named entity 'surface receptors' named entity 'complement factor' named entity 'PMNs' named entity 'receptor' named entity 'immune functions' named entity 'CD10' named entity 'CD11b' named entity 'PMNs' named entity 'uremic' named entity 'CD14' named entity 'neutropenia'

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