About: In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection

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About: In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection
Creator	Beltramello, M De Alwis, R Messer, W Sukupolvi-Petty, S Wahala, Wmpb
Source	PMC
abstract	Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection. Affected individuals also generate cross-reactive antibodies against heterologous DENV serotypes, which are non-neutralizing. Dengue cross-reactive, non-neutralizing antibodies can enhance infection of Fc receptor bearing cells and, potentially, exacerbate disease. The actual binding sites of human antibody on the DENV particle are not well defined. We characterized the specificity and neutralization potency of polyclonal serum antibodies and memory B-cell derived monoclonal antibodies (hMAbs) from 2 individuals exposed to primary DENV infections. Most DENV-specific hMAbs were serotype cross-reactive and weakly neutralizing. Moreover, many hMAbs bound to the viral pre-membrane protein and other sites on the virus that were not preserved when the viral envelope protein was produced as a soluble, recombinant antigen (rE protein). Nonetheless, by modifying the screening procedure to detect rare antibodies that bound to rE, we were able to isolate and map human antibodies that strongly neutralized the homologous serotype of DENV. Our MAbs results indicate that, in these two individuals exposed to primary DENV infections, a small fraction of the total antibody response was responsible for virus neutralization.
has issue date	2011-06-21(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0001188
bibo:pmid	21713020
has license	cc-by
sha1sum (hex)	01e22956c79df3220a67bce71cf22de95d29b723
schema:url	https://doi.org/10.1371/journal.pntd.0001188
resource representing a document's title	In-Depth Analysis of the Antibody Response of Individuals Exposed to Primary Dengue Virus Infection
has PubMed Central identifier	PMC3119640
has PubMed identifier	21713020
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:01e22956c79df3220a67bce71cf22de95d29b723#body_text
is schema:about of	named entity 'THESE' named entity 'INFECTION' named entity 'NOT WELL' named entity 'SEROTYPES' named entity 'INDIVIDUALS' named entity 'OUR' named entity 'RARE' named entity 'BEARING' named entity 'PROTEIN ' named entity 'TO DETECT' named entity 'HUMAN' named entity 'SERUM' named entity 'SPECIFICITY' named entity 'GENERATE' named entity 'AFFECTED' named entity 'EXPOSED TO' named entity 'antibodies' named entity 'infections' named entity 'defined' named entity 'cells' named entity 'antibodies' named entity 'individuals' named entity 'potency' named entity 'Individuals' named entity 'Dengue Virus' named entity 'PRIMARY' named entity 'SOLUBLE' named entity 'PRIMARY' named entity 'MONOCLONAL ANTIBODIES' named entity 'SMALL' named entity 'TOTAL' named entity 'ANTIBODIES' named entity 'SEROTYPE' named entity 'ISOLATE' named entity 'POTENCY' named entity 'CHARACTERIZED' named entity 'VIRUS' named entity 'MODIFYING' named entity 'EXACERBATE' named entity 'SCREENING PROCEDURE' named entity 'ANTIBODY' named entity 'EXPERIENCE' named entity 'BINDING SITES' named entity 'DERIVED' named entity 'ANTIBODY RESPONSE' named entity 'DENGUE VIRUS INFECTION' named entity 'EXPOSED TO' named entity 'INDIVIDUALS' named entity 'DEPTH' named entity 'ANTIBODY RESPONSE' named entity 'POLYCLONAL' named entity 'PROTEIN' named entity 'HUMANS' named entity 'RESULTS' named entity 'MEMORY B-CELL' named entity 'FC RECEPTOR' named entity 'RECOMBINANT ANTIGEN' named entity 'VIRAL ENVELOPE' named entity 'VIRUS NEUTRALIZATION' named entity 'SITES' named entity 'WELL DEFINED' named entity 'ANALYSIS' named entity 'RESPONSIBLE' named entity 'PRE' named entity 'INFECTIONS' named entity 'FRACTION OF' named entity 'DENGUE' named entity 'NON-' named entity 'SPECIFIC' named entity 'DISEASE' named entity 'VIRAL' named entity 'PARTICLE' named entity 'HETEROLOGOUS' named entity 'DENGUE VIRUS' named entity 'ENHANCE' named entity 'ACTUAL' named entity 'PRESERVED'

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