About: Viral Genome-Linked Protein (VPg) Is Essential for Translation Initiation of Rabbit Hemorrhagic Disease Virus (RHDV)

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About: Viral Genome-Linked Protein (VPg) Is Essential for Translation Initiation of Rabbit Hemorrhagic Disease Virus (RHDV) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral Genome-Linked Protein (VPg) Is Essential for Translation Initiation of Rabbit Hemorrhagic Disease Virus (RHDV)
Creator	Zhu, Jie Wang, Binbin Li, Chuanfeng Liu, Guangqing Chen, Zongyan Guo, Huimin Miao, Qiuhong Tan, Yonggui
Source	Medline; PMC
abstract	Rabbit hemorrhagic disease virus (RHDV), the causative agent of rabbit hemorrhagic disease, is an important member of the caliciviridae family. Currently, no suitable tissue culture system is available for proliferating RHDV, limiting the study of the pathogenesis of RHDV. In addition, the mechanisms underlying RHDV translation and replication are largely unknown compared with other caliciviridae viruses. The RHDV replicon recently constructed in our laboratory provides an appropriate model to study the pathogenesis of RHDV without in vitro RHDV propagation and culture. Using this RHDV replicon, we demonstrated that the viral genome-linked protein (VPg) is essential for RHDV translation in RK-13 cells for the first time. In addition, we showed that VPg interacts with eukaryotic initiation factor 4E (eIF4E) in vivo and in vitro and that eIF4E silencing inhibits RHDV translation, suggesting the interaction between VPg and eIF4E is involved in RHDV translation. Our results support the hypothesis that VPg serves as a novel cap substitute during the initiation of RHDV translation.
has issue date	2015-11-23(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0143467
bibo:pmid	26599265
has license	cc-by
sha1sum (hex)	01e59fdda1b5efc2ad16235eb7084b39dbfac513
schema:url	https://doi.org/10.1371/journal.pone.0143467
resource representing a document's title	Viral Genome-Linked Protein (VPg) Is Essential for Translation Initiation of Rabbit Hemorrhagic Disease Virus (RHDV)
has PubMed Central identifier	PMC4657913
has PubMed identifier	26599265
schema:publication	PLoS One
resource representing a document's body	covid:01e59fdda1b5efc2ad16235eb7084b39dbfac513#body_text
is schema:about of	named entity 'compared' named entity 'mechanisms' named entity 'demonstrated' named entity 'initiation' named entity 'model' named entity 'Viral' named entity 'OUR' named entity 'causative' named entity 'VPg' named entity 'VPg' named entity 'study' named entity 'study' named entity 'Our' named entity 'cap' named entity 'VPg' named entity 'RHDV' named entity 'RNA' named entity 'initiation factors' named entity 'cDNA' named entity 'translation initiation' named entity 'ORF1' named entity 'Cardiovirus' named entity 'mRNA' named entity 'Takara' named entity 'protein' named entity 'plasmid' named entity 'VPg' named entity 'culture' named entity 'Rabbit Hemorrhagic Disease Virus' named entity 'rabbit hemorrhagic disease' named entity 'RHDV' named entity 'RHDV' named entity 'RHDV' named entity 'RHDV' named entity 'viral genome-linked protein' named entity 'RHDV' named entity 'replicon' named entity 'RHDV' named entity 'Translation Initiation' named entity 'subcloned' named entity 'eIF4E' named entity 'RHDV' named entity 'replicon' named entity 'cell lysate' named entity 'eIF4E' named entity 'DNA-binding domains' named entity 'eIF3' named entity 'XbaI' named entity 'genome' named entity 'protein' named entity 'transcriptional activation' named entity 'plasmid' named entity 'cDNA' named entity 'virus' named entity 'plasmid' named entity '37°C' named entity 'China' named entity 'eukaryotic initiation factor 4E' named entity 'RHDV' named entity 'turnip mosaic virus' named entity 'polyclonal antibodies' named entity 'gene' named entity 'PBS' named entity 'RHDV' named entity 'RNA' named entity 'VPg' named entity 'China' named entity 'vector' named entity 'RHDV' named entity 'qRT-PCR' named entity 'VPg' named entity 'RHDV' named entity 'luciferase' named entity 'vector'

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