About: Analysis of Ebola Virus Entry Into Macrophages

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Analysis of Ebola Virus Entry Into Macrophages
Creator	Herrler, Georg Bertram, Stephanie Pöhlmann, Stefan Hofmann-Winkler, Heike Becker, Stephan Gnirß, Kerstin Wrensch, Florian Schneider, Heike Dahlmann, Franziska Babler, Anne Biedenkopf, Nadine Jahnen-Dechent, Willi Karsten, Christina O'callaghan, Christopher
source	Medline; PMC
abstract	Ebolaviruses constitute a public health threat, particularly in Central and Western Africa. Host cell factors required for spread of ebolaviruses may serve as targets for antiviral intervention. Lectins, TAM receptor tyrosine kinases (Tyro3, Axl, Mer), T cell immunoglobulin and mucin domain (TIM) proteins, integrins, and Niemann-Pick C1 (NPC1) have been reported to promote entry of ebolaviruses into certain cellular systems. However, the factors used by ebolaviruses to invade macrophages, major viral targets, are poorly defined. Here, we show that mannose-specific lectins, TIM-1 and Axl augment entry into certain cell lines but do not contribute to Ebola virus (EBOV)-glycoprotein (GP)–driven transduction of macrophages. In contrast, expression of Mer, integrin αV, and NPC1 was required for efficient GP-mediated transduction and EBOV infection of macrophages. These results define cellular factors hijacked by EBOV for entry into macrophages and, considering that Mer and integrin αV promote phagocytosis of apoptotic cells, support the concept that EBOV relies on apoptotic mimicry to invade target cells.
has issue date	2015-10-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jiv140
bibo:pmid	25877552
has license	cc-by-nc-nd
sha1sum (hex)	02522a1b4512e4d2880a6a551a8dff589d4cb393
schema:url	https://doi.org/10.1093/infdis/jiv140
resource representing a document's title	Analysis of Ebola Virus Entry Into Macrophages
has PubMed Central identifier	PMC4564540
has PubMed identifier	25877552
schema:publication	J Infect Dis
resource representing a document's body	covid:02522a1b4512e4d2880a6a551a8dff589d4cb393#body_text
is schema:about of	named entity 'Central' named entity 'driven' named entity 'infection' named entity 'EBOV' covid:arg/02522a1b4512e4d2880a6a551a8dff589d4cb393 named entity 'TARGETS' named entity 'MANNOSE' named entity 'CONSIDERING' named entity 'TIM-1' named entity 'THESE' named entity 'WESTERN AFRICA' named entity 'INVADE' named entity 'SPREAD' named entity 'THREAT' named entity 'DRIVEN' named entity 'SERVE' named entity 'TAM' named entity 'PUBLIC HEALTH' named entity 'ENTRY' named entity 'POORLY DEFINED' named entity 'REPORTED' named entity 'MER' named entity 'GLYCOPROTEIN' named entity 'EBOLA VIRUS' named entity 'MACROPHAGES' named entity 'NPC1' named entity 'REQUIRED' named entity 'VIRUS ENTRY' named entity 'ANALYSIS' named entity 'LECTINS' named entity 'T CELL' named entity 'TYROSINE KINASES' named entity 'CONTRAST' named entity 'ANTIVIRAL' named entity 'VIRAL' named entity 'CONCEPT' named entity 'INFECTION' named entity 'CELLS' named entity 'RECEPTOR' named entity 'CELLULAR SYSTEMS' named entity 'DOMAIN' named entity 'SUPPORT' named entity 'IMMUNOGLOBULIN' named entity 'PROMOTE' named entity 'CELL LINES' named entity 'AUGMENT' named entity 'EXPRESSION' named entity 'HOST CELL' named entity 'HERE' named entity 'APOPTOTIC' named entity 'RESULTS' named entity 'CONTRIBUTE ' named entity 'MACROPHAGES' named entity 'TRANSDUCTION' named entity 'PICK' named entity 'BUT' named entity 'AXL' named entity 'INTERVENTION' named entity 'USED BY' named entity 'CENTRAL' named entity 'CERTAIN' named entity 'INTEGRINS' named entity 'EFFICIENT' named entity 'PROTEINS' named entity 'EBOLA VIRUS' named entity 'HAVE' named entity 'MUCIN' named entity 'TARGET CELLS'

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