About: Increase in placental apolipoprotein D as an adaptation to human gestational diabetes

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About: Increase in placental apolipoprotein D as an adaptation to human gestational diabetes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increase in placental apolipoprotein D as an adaptation to human gestational diabetes
Creator	Alonso, A Celular, Biología Garrido, P Gonzá Lez C, C Gonzá Lez Del Rey, C Morfología, Dpto Navarro, A Ordoñ Ez, C Tolivia, J
topic	covid:025caa475da8ddd8fff850c4a42eb1c0317db8c2#this
Source	Elsevier; Medline; PMC
abstract	Abstract The expression of apolipoprotein D (apo D), a lipocalin involved in defense mechanisms against oxidative stress, in placental tissue samples of pregnancies with gestational diabetes mellitus (GDM) was compared to non-diabetic controls. We have investigated the relationship of apo D with 4-HNE, a major propagation product of lipid peroxidation, in stressed tissues. We included 20 pregnant women with GDM and 30 women with normal ongoing pregnancies as the control group. Placentas were collected and frozen for Western blot or included in paraffin for immunohistochemistry. The intensity of immunostaining was higher for apo D and 4-HNE in GDM samples; however, the differences in expression between the groups was more intense for apo D. Positive signals for both antibodies was detected in the villous trophoblast and adventitia tunica around the large blood vessels for all groups. Specific immunostaining for apo D was noted in some mesenchymal and macrophagic-like cells and this signal increased in diabetic placentas. Densitometry analysis of Western blots showed no significant difference for 4-HNE, but was significantly more intense for apo D in diabetic women. The contradictory results for 4-HNE could be due to changes which are too small and are masked in tissue homogenates. The results for apo D showed a strong relationship with GDM in the placenta that may reflect its suggested function in defense mechanisms against oxidative stress.
has issue date	2010-01-31(xsd:dateTime)
bibo:doi	10.1016/j.placenta.2009.11.002
bibo:pmid	19944460
has license	els-covid
sha1sum (hex)	025caa475da8ddd8fff850c4a42eb1c0317db8c2
schema:url	https://doi.org/10.1016/j.placenta.2009.11.002
resource representing a document's title	Increase in placental apolipoprotein D as an adaptation to human gestational diabetes
has PubMed Central identifier	PMC7124627
has PubMed identifier	19944460
schema:publication	Placenta
resource representing a document's body	covid:025caa475da8ddd8fff850c4a42eb1c0317db8c2#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/025caa475da8ddd8fff850c4a42eb1c0317db8c2
is schema:about of	named entity 'groups' named entity 'mesenchymal' named entity 'placenta' named entity 'blots' named entity 'gestational diabetes' named entity 'ONGOING' named entity 'REFLECT' named entity 'PLACENTAS' named entity 'GDM' named entity 'RELATIONSHIP' named entity 'NORMAL' named entity 'LARGE' named entity 'TISSUE' named entity 'INTENSE' named entity 'INVESTIGATED' named entity 'COLLECTED' named entity 'SAMPLES' named entity 'TUNICA ' named entity 'WESTERN BLOT' named entity 'CELLS' named entity 'PLACENTAL TISSUE' named entity 'FUNCTION' named entity 'HAVE' named entity 'APO' named entity 'TISSUES' named entity 'ANALYSIS' named entity 'A MAJOR' named entity 'IMMUNOSTAINING' named entity 'PARAFFIN' named entity '4-HNE' named entity 'DETECTED' named entity 'BLOOD VESSELS' named entity 'PRODUCT' covid:arg/025caa475da8ddd8fff850c4a42eb1c0317db8c2 named entity 'GESTATIONAL DIABETES' named entity 'PLACENTAL' named entity 'APOLIPOPROTEIN D' named entity 'POSITIVE' named entity 'SIGNALS' named entity 'FROZEN' named entity 'DIABETIC' named entity 'NOTED' named entity 'HIGHER' named entity 'LIPID PEROXIDATION' named entity 'GESTATIONAL DIABETES MELLITUS' named entity 'LIPOCALIN' named entity 'APOLIPOPROTEIN D' named entity 'DUE TO' named entity 'NON-' named entity 'ANTIBODIES' named entity 'INVOLVED' named entity 'STRONG' named entity 'RESULTS' named entity 'GROUPS' named entity 'COULD BE' named entity 'TOO SMALL' named entity 'INCLUDED' named entity 'PREGNANT WOMEN' named entity 'HUMAN' named entity 'INCREASE' named entity 'PROPAGATION' named entity 'DEFENSE MECHANISMS' named entity 'DIFFERENCE' named entity 'CHANGES' named entity 'PREGNANCIES' named entity 'ITS' named entity 'LIKE' named entity 'SIGNIFICANT' named entity 'INTENSITY' named entity 'ADVENTITIA' named entity 'MASKED'

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