About: Clinical features and outcomes of inpatients with neurological disease and COVID-19

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Clinical features and outcomes of inpatients with neurological disease and COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical features and outcomes of inpatients with neurological disease and COVID-19
Creator	Filosto, Massimiliano Agosti, Chiara Alberici, Antonella Baldelli, Enrico Benini, Matteo Benussi, Alberto Bonacina, Sonia Borroni, Barbara Brambilla, Laura Caratozzolo, Salvatore Cortinovis, Matteo Costa, Angelo Cottini, Elisabetta Cristillo, Viviana Delrio, Ilenia Gamba, Massimo Gazzina, Stefano Gilberti, Nicola Gipponi, Stefano Giunta, Marcello Imarisio, Alberto Invernizzi, Paolo Leonardi, Matilde Leggio, Ugo Liberini, Paolo Libri, Ilenia Locatelli, Martina Magoni, Mauro Masciocchi, Stefano Padovani, Alessandro Pezzini, Alessandro Piccinelli, Stefano Pilotto, Andrea Poli, Loris Premi, Enrico Rao, Renata Risi, Barbara Rozzini, Luca Scalvini, Andrea Schiano Di Cola, Francesca Spezi, Raffaella Vergani, Veronica Volonghi, Irene Zoppi, Nicola
source	MedRxiv
abstract	Objective: To report the clinical and laboratory characteristics, as well as treatment and clinical outcomes of patients admitted for neurological diseases with COVID-19 in a Neuro-COVID unit compared to patients without COVID-19. Methods: In this retrospective, single centre cohort study, we included all adult inpatients with confirmed COVID-19, who had been discharged or died by April 5, 2020. Demographic, clinical, treatment, and laboratory data were extracted from medical records. Results: 173 patients were included in this study, of whom 56 resulted positive for COVID-19 and 117 resulted negative for COVID-19. Patients with COVID-19 were older, had a different distribution regarding admission diagnoses, including cerebrovascular disorders, and had a higher quick Sequential Organ Failure Assessment (qSOFA) score on admission (all p<0.05). In-hospital mortality rates and incident delirium were significantly higher in the COVID-19 group (all p<0.05). COVID-19 and non-COVID patients with stroke had similar baseline characteristics but patients with COVID-19 had higher modified Rankin scale scores at discharge (p<0.0001), with a significantly lower number of patients with a good outcome (p<0.0001). Multivariable regressions showed increasing odds of in-hospital death associated with higher qSOFA scores (odds ratio 4.47, 95% CI 1.21-16.5; p=0.025), lower platelet count (0.98, 0.97-0.99; p=0.005) and higher lactate dehydrogenase (1.01, 1.00-1.03; p=0.009) on admission. Conclusions: COVID-19 patients admitted with neurological disease, including stroke, have a significantly higher in-hospital mortality, incident delirium and higher disability than patients without COVID-19.
has issue date	2020-05-02(xsd:dateTime)
bibo:doi	10.1101/2020.04.28.20082735
has license	medrxiv
sha1sum (hex)	027999497b4bb9837f53295f752def86671e002c
schema:url	https://doi.org/10.1101/2020.04.28.20082735
resource representing a document's title	Clinical features and outcomes of inpatients with neurological disease and COVID-19
resource representing a document's body	covid:027999497b4bb9837f53295f752def86671e002c#body_text
is schema:about of	named entity 'qSOFA' named entity 'FAILURE ASSESSMENT' named entity 'LABORATORY' named entity 'TREATMENT AND CLINICAL OUTCOMES' named entity 'Organ' named entity 'admission' named entity 'Failure' named entity 'neurological diseases' named entity 'qSOFA' named entity 'Organ Failure' named entity 'Clinical features' named entity 'lymphocyte count' named entity 'fibrinogen' named entity 'medRxiv' named entity 'stroke' named entity 'preprint' named entity 'sample size' named entity 'transient ischemic attack' named entity 'erythrocyte sedimentation rate' named entity 'Italy' named entity 'upper respiratory tract' named entity 'neurological disease' named entity 'COVID' named entity 'C-reactive protein' named entity 'medRxiv' named entity 'preprint' named entity 'medRxiv' named entity 'ferritin' named entity 'peer review' named entity 'ritonavir' named entity 'intravenous' named entity 'delirium' named entity 'COVID-19' named entity 'prognosis' named entity 'neutrophil' named entity 'ASA' named entity 'COVID-19' named entity 'preprint' named entity 'stroke' named entity 'vascular endothelial cells' named entity 'multiple comparisons' named entity 'COVID'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software