About: Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters

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About: Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters
Creator	Imai, Yumiko Kuba, Keiji Ohto-Nakanishi, Takayo Penninger, Josef
Source	Elsevier; Medline; PMC
abstract	Angiotensin-converting enzyme (ACE) 2 is a homolog to the carboxypeptidase ACE, which generates angiotensin II, the main active peptide of renin–angiotensin system (RAS). After the cloning of ACE2 in 2000, three major ACE2 functions have been described so far. First ACE2 has emerged as a potent negative regulator of the RAS counterbalancing the multiple functions of ACE. By targeting angiotensin II ACE2 exhibits a protective role in the cardiovascular system and many other organs. Second ACE2 was identified as an essential receptor for the SARS coronavirus that causes severe acute lung failure. Downregulation of ACE2 strongly contributes to the pathogenesis of severe lung failure. Third, both ACE2 and its homologue Collectrin can associate with amino acid transporters and play essential role in the absorption of amino acids in the kidney and gut. In this review, we will discuss the multiple biological functions of ACE2.
has issue date	2010-07-03(xsd:dateTime)
bibo:doi	10.1016/j.pharmthera.2010.06.003
bibo:pmid	20599443
has license	no-cc
sha1sum (hex)	02d18b4f484a0420c21595a95b8765125d4a484c
schema:url	https://doi.org/10.1016/j.pharmthera.2010.06.003
resource representing a document's title	Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters
has PubMed Central identifier	PMC7112678
has PubMed identifier	20599443
schema:publication	Pharmacol Ther
resource representing a document's body	covid:02d18b4f484a0420c21595a95b8765125d4a484c#body_text
is schema:about of	named entity 'ACE2' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'ACE2' named entity 'receptor' named entity 'acute' named entity 'potent' named entity 'associate' named entity 'negative regulator' named entity 'TRANSPORTERS' named entity 'ABSORPTION' named entity 'HOMOLOGUE' named entity 'ASSOCIATE' named entity 'MULTIPLE' named entity 'KIDNEY' named entity 'ORGANS' named entity 'RECEPTOR' named entity 'REVIEW' named entity 'LUNG' named entity 'CLONING' named entity 'PATHOGENESIS' named entity 'DISCUSS' named entity 'IS A' named entity 'EXHIBITS' named entity 'ACTIVE PEPTIDE' named entity 'CARBOXYPEPTIDASE' named entity 'GUT' covid:arg/02d18b4f484a0420c21595a95b8765125d4a484c named entity 'AMINO ACID' named entity 'NEGATIVE REGULATOR' named entity 'BIOLOGICAL FUNCTIONS' named entity 'RAS' named entity 'AMINO ACIDS' named entity 'AMINO ACID' named entity 'IDENTIFIED' named entity 'ANGIOTENSIN II' named entity 'CAUSES' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'DOWNREGULATION' named entity 'CARDIOVASCULAR SYSTEM' named entity 'FUNCTIONS' named entity 'ACE' named entity 'KEYWORDS' named entity 'AMINO ACID TRANSPORTER' named entity 'SARS' named entity 'FAILURE' named entity 'ESSENTIAL' named entity '2000' named entity 'SARS CORONAVIRUS' named entity 'PARTNER' named entity 'RECEPTOR' named entity 'PEPTIDASE' named entity 'HAVE' named entity 'PLAY' named entity 'SARS' named entity 'SEVERE' named entity 'DESCRIBED' named entity 'PROTECTIVE ROLE' named entity 'ROLE' named entity 'ANGIOTENSIN-CONVERTING ENZYME' named entity 'COLLECTRIN' named entity 'ACE2' named entity 'HOMOLOG' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'TARGETING' named entity 'TRANSPORTERS' named entity 'MAIN' named entity 'FAR' named entity 'ITS' named entity 'ACUTE' named entity 'MAJOR' named entity 'SECOND' named entity 'absorption' named entity 'kidney' named entity 'ACE2' named entity 'targeting' named entity 'lung failure' named entity 'peptide' named entity 'ACE2'

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