About: Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein

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About: Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein
Creator	Ko, Tzu-Ping Tang, Tswen-Kei Hsu, Chun-Hua Chen, Shui-Tsung Yu, Hui-Ming Wang, -J Wang, H.-J
Source	Elsevier; Medline; PMC
abstract	Abstract The SARS-CoV spike protein, a glycoprotein essential for viral entry, is a primary target for vaccine and drug development. Two peptides denoted HR-N(SN50) and HR-C(SC40), corresponding to the Leu/Ile/Val-rich heptad-repeat regions from the N-terminal and C-terminal segments of the SARS-CoV spike S2 sequence, respectively, were synthesized and predicted to form trimeric assembly of hairpin-like structures. The polyclonal antibodies produced by recombinant S2 protein were tested for antigenicity of the two heptad repeats. We report here the first crystallographic study of the SARS spike HR-N/HR-C complex. The crystal belongs to the triclinic space group P1 and the data-set collected to 2.98Å resolution showed noncrystallographic pseudo-222 and 3-fold symmetries. Based on these data, comparative modeling of the SARS-CoV fusion core was performed. The immunological and structural information presented herein may provide a more detailed understanding of the viral fusion mechanism as well as the development of effective therapy against SARS-CoV infection.
has issue date	2004-11-12(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2004.09.116
bibo:pmid	15474492
has license	els-covid
sha1sum (hex)	02f9bedabfc54b777273a22aa4d1a343cebc6133
schema:url	https://doi.org/10.1016/j.bbrc.2004.09.116
resource representing a document's title	Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein
has PubMed Central identifier	PMC7092949
has PubMed identifier	15474492
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:02f9bedabfc54b777273a22aa4d1a343cebc6133#body_text
is schema:about of	named entity 'X-RAY DIFFRACTION' named entity 'SARS' named entity 'GLYCOPROTEIN' named entity 'SPACE GROUP' named entity 'DRUG DEVELOPMENT' named entity 'CORE' named entity 'SARS-COV' named entity 'DEVELOPMENT' named entity 'PRIMARY' named entity 'PEPTIDES' named entity 'SYMMETRIES' named entity 'TO FORM' named entity 'DETAILED' named entity 'SARS' named entity 'MECHANISM' named entity 'SYNTHESIZED' named entity 'VIRAL ENTRY' named entity 'SET' named entity 'TARGET' named entity 'DATA' named entity 'INFORMATION' covid:arg/02f9bedabfc54b777273a22aa4d1a343cebc6133 named entity 'THERAPY' named entity 'SARS-COV INFECTION' named entity 'IMMUNOLOGICAL' named entity 'IS A' named entity 'COMPLEX' named entity 'VACCINE' named entity 'COLLECTED' named entity 'BASED' named entity 'RECOMBINANT' named entity 'LIKE' named entity 'REPEAT' named entity 'HERE' named entity 'REPORT' named entity 'REGIONS' named entity 'UNDERSTANDING' named entity 'ESSENTIAL' named entity 'STRUCTURAL' named entity 'LEU' named entity 'CORONAVIRUS' named entity 'PRELIMINARY' named entity 'FUSION' named entity 'CORE' named entity 'IMMUNOLOGICAL' named entity 'PROTEIN ' named entity 'STRUCTURAL' named entity 'TESTED FOR' named entity 'EFFECTIVE' named entity 'PREDICTED' named entity 'ASSEMBLY' named entity 'SEQUENCE' named entity 'FOLD' named entity 'PROTEIN ' named entity 'PSEUDO' named entity 'SPIKE PROTEIN' named entity 'COMPARATIVE MODELING' named entity 'PROVIDE' named entity 'GROUP P1' named entity 'SPIKE' named entity 'RICH' named entity 'PERFORMED' named entity 'THESE' named entity 'FUSION' named entity 'POLYCLONAL ANTIBODIES' named entity 'REPEATS' named entity 'N-TERMINAL ' named entity 'ANTIGENICITY' named entity 'SPIKE PROTEIN' named entity 'STUDY' named entity 'TRICLINIC' named entity '222' named entity 'SEGMENTS' named entity 'VIRAL' named entity 'C-TERMINAL'

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