About: Generating Nanotopography on PCL Microfiber Surface for Better Cell-Scaffold Interactions

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About: Generating Nanotopography on PCL Microfiber Surface for Better Cell-Scaffold Interactions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Generating Nanotopography on PCL Microfiber Surface for Better Cell-Scaffold Interactions
Creator	Sun, Jie Liu, Hang Huang, Dejian Jing, Linzhi
Source	Elsevier
abstract	Abstract To understand the behavior of cells in natural environment, 3D scaffolds are needed to provide biomimetic environment for routine cell growth in vitro. Electrohydrodynamic jet (EHDJ) printing, one of the emerging 3D printing techniques, is capable of fabricating 3D scaffolds with oriented fibers and customized microscale structures. However, most of the EHDJ-printed scaffolds lack of hierarchical structures such as nanotopographies present in native tissues. In this study, we propose a novel approach that combine EHDJ printing of poly(ε-caprolactone) (PCL)/gliadin composite inks to produce scaffolds with oriented microfibers. The nanoscale pores and flaws (fiber nanotopography) could be generated on the printed fibers by simply leaching the gliadin phase from the printed PCL/gliadin scaffolds. The density and size of nanotopographical features could be controlled by adjusting the gliadin ratio. Furthermore, by seeding mouse embryonic fibroblasts (NIH/3T3) cells, it clearly manifested that such scaffolds are favorable to cell adhesion, migration and proliferation efficiently. Thus, the newly designed PCL scaffolds with both micro- and nano-scale topographies can be a promising 3D cell culture platform with improved cell-scaffold interactions.
has issue date	2020-12-31(xsd:dateTime)
bibo:doi	10.1016/j.promfg.2020.05.090
has license	els-covid
sha1sum (hex)	03025d92bdc70cdb1c90e312fa87ff2d5eec2c4d
schema:url	https://doi.org/10.1016/j.promfg.2020.05.090
resource representing a document's title	Generating Nanotopography on PCL Microfiber Surface for Better Cell-Scaffold Interactions
schema:publication	Procedia Manufacturing
resource representing a document's body	covid:03025d92bdc70cdb1c90e312fa87ff2d5eec2c4d#body_text
is schema:about of	named entity 'behavior' named entity 'printing' named entity 'embryonic' named entity 'provide' named entity 'PCL' named entity 'ScienceDirect' named entity 'Microfiber' named entity 'PLATFORM' named entity 'TECHNIQUES' named entity 'SIZE' named entity 'NANOTOPOGRAPHY' named entity 'CONTROLLED BY' named entity 'CELLS' named entity 'LACK' named entity 'CAPABLE' named entity 'NEEDED' named entity 'CUSTOMIZED' named entity 'ONE OF' named entity 'IN VITRO' named entity 'TO PROVIDE' named entity 'JET' named entity 'NEWLY' named entity 'However' named entity 'topographies' named entity 'phase' named entity '3D printing' named entity '3D cell culture' named entity 'gliadin' named entity 'density' named entity 'composite' named entity 'flaws' named entity 'biomimetic' named entity 'gliadin' named entity 'gliadin' named entity 'nano-scale' named entity 'nanoscale' named entity 'NIH' named entity 'Nanotopography' named entity 'nanoscale' named entity 'time jet' named entity 'gingival' named entity 'physical interaction' named entity 'Young's modulus' named entity 'gliadin' named entity 'epoxy' named entity 'tensile forces' named entity '3D cell culture' named entity 'gliadin' named entity 'titanium' named entity 'solubility' named entity 'protein' named entity 'Assay' named entity 'jet printing' named entity 'cell adhesion' named entity 'nanoporous' named entity 'lattice' named entity 'biochemical' named entity 'breaking strain' named entity 'extracellular matrix' named entity 'orders of magnitude' named entity 'red arrows' named entity 'gliadin' named entity 'micrometer' named entity 'fibroblast cells' named entity 'nozzle' named entity 'fibroblasts' named entity 'porous' named entity 'Microstructural' named entity 'cellular functions' named entity 'biointerface' named entity 'silk fibroin' named entity 'dashed' named entity 'gliadin' named entity 'substrate' named entity 'substrate' named entity 'gliadin' named entity 'fibroblasts' named entity 'epoxy' named entity 'substrate' named entity 'nanotopography' named entity 'gliadin'

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