About: Recombination Every Day: Abundant Recombination in a Virus during a Single Multi-Cellular Host Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Recombination Every Day: Abundant Recombination in a Virus during a Single Multi-Cellular Host Infection
Creator	Blanc, Stephane Froissart, Remy Galibert, Lionel Michalakis, Yannis Roze, Denis Uzest, Marilyne
source	PMC
abstract	Viral recombination can dramatically impact evolution and epidemiology. In viruses, the recombination rate depends on the frequency of genetic exchange between different viral genomes within an infected host cell and on the frequency at which such co-infections occur. While the recombination rate has been recently evaluated in experimentally co-infected cell cultures for several viruses, direct quantification at the most biologically significant level, that of a host infection, is still lacking. This study fills this gap using the cauliflower mosaic virus as a model. We distributed four neutral markers along the viral genome, and co-inoculated host plants with marker-containing and wild-type viruses. The frequency of recombinant genomes was evaluated 21 d post-inoculation. On average, over 50% of viral genomes recovered after a single host infection were recombinants, clearly indicating that recombination is very frequent in this virus. Estimates of the recombination rate show that all regions of the genome are equally affected by this process. Assuming that ten viral replication cycles occurred during our experiment—based on data on the timing of coat protein detection—the per base and replication cycle recombination rate was on the order of 2 × 10(−5) to 4 × 10(−5). This first determination of a virus recombination rate during a single multi-cellular host infection indicates that recombination is very frequent in the everyday life of this virus.
has issue date	2005-03-01(xsd:dateTime)
bibo:doi	10.1371/journal.pbio.0030089
bibo:pmid	15737066
has license	cc-by
sha1sum (hex)	03203ab50eb64271a9e825f94a1b1a6c46ea14b3
schema:url	https://doi.org/10.1371/journal.pbio.0030089
resource representing a document's title	Recombination Every Day: Abundant Recombination in a Virus during a Single Multi-Cellular Host Infection
has PubMed Central identifier	PMC1054884
has PubMed identifier	15737066
schema:publication	PLoS Biol
resource representing a document's body	covid:03203ab50eb64271a9e825f94a1b1a6c46ea14b3#body_text
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