About: The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteins

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About: The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteins
Creator	Godzik, Adam Alisoltani, Arghavan Iyer, Mallika Jaroszewski, Lukasz Sedova, Mayya
Source	BioRxiv; Medline; PMC
abstract	Fast evolution of the SARS-CoV-2 virus provides us with unique information about the patterns of genetic changes in a single pathogen in the timescale of months. This data is used extensively to track the phylodynamic of the pandemic’s spread and its split into distinct clades. Here we show that the patterns of SARS-CoV-2 virus mutations along its genome are closely correlated with the structural features of the coded proteins. We show that the foldability of proteins’ 3D structures and conservation of their functions are the universal factors driving evolutionary selection in protein-coding genes. Insights from the analysis of mutation distribution in the context of the SARS-CoV-2 proteins’ structures and functions have practical implications including evaluating potential antigen epitopes or selection of primers for PCR-based COVID-19 tests.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1101/2020.08.10.244756
bibo:pmid	32817947
has license	cc-by-nc
sha1sum (hex)	03560584c098d265319a71afc42d687755dd5a88
schema:url	https://doi.org/10.1101/2020.08.10.244756
resource representing a document's title	The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteins
has PubMed Central identifier	PMC7430578
has PubMed identifier	32817947
schema:publication	bioRxiv
resource representing a document's body	covid:03560584c098d265319a71afc42d687755dd5a88#body_text
is schema:about of	named entity 'COVID-19' named entity 'selection' named entity 'context' named entity 'evolution' named entity 'structures' named entity 'proteins' named entity 'functionality' named entity 'evolution' named entity 'potential' named entity 'genome' named entity 'pathogen' named entity 'PDB' named entity 'epitopes' named entity 'virus' named entity 'antibodies' named entity 'p-values' named entity 'genome' named entity 'missense mutations' named entity 'virus' named entity 'SARS-CoV-2' named entity 'genome' named entity 'SARS-CoV-2' named entity 'driving' named entity 'coded' named entity 'correlated' named entity 'pathogen' named entity 'epitopes' named entity 'COVID-19 tests' named entity 'SARS-CoV-2' named entity 'evaluating' named entity 'cancer genomics' named entity 'region coding' named entity 'protein' named entity 'missense mutations' named entity 'diagnostic tests' named entity 'PCR' named entity 'genomes' named entity 'clades' named entity 'protein' named entity 'mutation' named entity 'amino-acid' named entity 'viral replication' named entity 'epitopes' named entity 'missense mutations' named entity 'sequenced' named entity 'missense mutations' named entity 'PCR primers' named entity 'epitopes' named entity 'mutation rate' named entity 'solvent exposure' named entity 'diagnostic tests' named entity 'epidemics' named entity 'clades' named entity 'tandem repeat' named entity 'null hypothesis' named entity 'R package' named entity 'protein' named entity 'Nucleocapsid protein' named entity 'ACE2 receptor' named entity 'protein-coding gene' named entity '3CLpro' named entity 'Spike protein' named entity 'proteome' named entity 'binding site' named entity 'dN/dS' named entity 'ACE2 receptor' named entity 'primers' named entity 'preprint' named entity 'metadata' named entity 'Covid-19' named entity 'missense mutations' named entity 'June 8' named entity 'RNA' named entity 'amino acid' named entity 'metadata' named entity 'reading frames' named entity 'genome'

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