About: Highly conserved M2e and hemagglutinin epitope-based recombinant proteins induce protection against influenza virus infection

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About: Highly conserved M2e and hemagglutinin epitope-based recombinant proteins induce protection against influenza virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Highly conserved M2e and hemagglutinin epitope-based recombinant proteins induce protection against influenza virus infection
Creator	Du, Lanying Guo, Yan Jiang, Shibo Zhao, Guangyu Zhou, Yusen Sun, Shihui Tai, Wanbo He, Lei Li, Pei Song, Nianping
Source	PMC
abstract	Highly pathogenic influenza viruses continue to cause serious threat to public health due to their pandemic potential, calling for an urgent need to develop effective, safe, convenient, and universal vaccines against influenza virus infection. In this study, we constructed two recombinant protein vaccines, 2H5M2e-2H7M2e-H5FP-H7FP (hereinafter M2e-FP-1) and 2H5M2e-H5FP-2H7M2e-H7FP (hereinafter M2e-FP-2), by respectively linking highly conserved sequences of two molecules of ectodomain of M2 (M2e) and one molecule of fusion peptide (FP) epitope of hemagglutinin (HA) of H5N1 and H7N9 influenza viruses in different orders. The Escherichia coli-expressed M2e-FP-1 and M2e-FP-2 proteins induced similarly high-titer M2e-FP-specific antibodies in the immunized mice. Importantly, both proteins were able to prevent lethal challenge of heterologous H1N1 influenza virus, with significantly reduced viral titers and alleviated pathological changes in the lungs, as well as increased body weight and complete survivals, in the challenge mice. Taken together, our study demonstrates that highly conserved M2e and FP epitope of HA of H5N1 and H7N9 influenza viruses can be used as important targets for development of safe and economical universal influenza vaccines, and that the position of H7N9 M2e and H5N1 HA epitope sequences in the vaccine components has no significant effects on the immunogenicity and efficacy of M2e-FP-based subunit vaccines.
has issue date	2017-09-10(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2017.08.010
bibo:pmid	28903071
has license	no-cc
sha1sum (hex)	03700b715526bc4a249901fe7d2be39241a09a41
schema:url	https://doi.org/10.1016/j.micinf.2017.08.010
resource representing a document's title	Highly conserved M2e and hemagglutinin epitope-based recombinant proteins induce protection against influenza virus infection
has PubMed Central identifier	PMC7110499
has PubMed identifier	28903071
schema:publication	Microbes Infect
resource representing a document's body	covid:03700b715526bc4a249901fe7d2be39241a09a41#body_text
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