About: An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus

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About: An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus
Creator	Kim, Jinhee Min, Ji-Young Kim, Hyori Ko, Meehyun Park, Wan Hyun, Ki Id, Chun Id, Junho Id, Kim Id, Oh Id, Seungtaek Young, June
Source	Medline; PMC
abstract	Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease localized to China, Japan, and Korea that is characterized by severe hemorrhage and a high fatality rate. Currently, no specific vaccine or treatment has been approved for this disease. To develop a therapeutic agent for SFTS, we isolated antibodies from a phage-displayed antibody library that was constructed from a patient who recovered from SFTS virus (SFTSV) infection. One antibody, designated as Ab10, was reactive to the Gn envelope glycoprotein of SFTSV and protected host cells and A129 mice from infection in both in vitro and in vivo experiments. Notably, Ab10 protected 80% of mice, even when injected 5 days after inoculation with a lethal dose of SFTSV. Using cross-linker assisted mass spectrometry and alanine scanning, we located the non-linear epitope of Ab10 on the Gn glycoprotein domain II and an unstructured stem region, suggesting that Ab10 may inhibit a conformational alteration that is critical for cell membrane fusion between the virus and host cell. Ab10 reacted to recombinant Gn glycoprotein in Gangwon/Korea/2012, HB28, and SD4 strains. Additionally, based on its epitope, we predict that Ab10 binds the Gn glycoprotein in 247 of 272 SFTSV isolates previously reported. Together, these data suggest that Ab10 has potential to be developed into a therapeutic agent that could protect against more than 90% of reported SFTSV isolates.
has issue date	2019-02-01(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1007375
bibo:pmid	30707748
has license	cc-by
sha1sum (hex)	03797126b6e6689cc02878e641e5271d3b9a5d3b
schema:url	https://doi.org/10.1371/journal.ppat.1007375
resource representing a document's title	An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus
has PubMed Central identifier	PMC6380599
has PubMed identifier	30707748
schema:publication	PLoS Pathog
resource representing a document's body	covid:03797126b6e6689cc02878e641e5271d3b9a5d3b#body_text
is schema:about of	named entity 'ANTIBODY' named entity 'thrombocytopenia' named entity 'mass spectrometry' named entity 'mice' named entity 'Korea' named entity 'agent' named entity 'mice' named entity 'antibody' named entity 'convalescent' named entity 'SEVERE HEMORRHAGE' named entity '80%' named entity 'INFECTION' named entity 'GLYCOPROTEIN' named entity 'BASED' named entity 'SFTS VIRUS' named entity 'POTENTIAL' named entity 'RECOVERED' named entity 'DATA' named entity 'ASSISTED' named entity 'DISEASE' named entity 'CHARACTERIZED' named entity 'VACCINE' named entity 'INOCULATION' named entity 'THESE' named entity 'PATIENT' named entity 'SPECIFIC' named entity 'REPORTED' named entity 'SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME' named entity 'SUGGEST' named entity 'HOST CELLS' named entity 'NON-LINEAR' named entity 'ALANINE SCANNING' named entity 'DISEASE LOCALIZED' named entity 'HIGH' named entity 'CROSS' named entity 'CONVALESCENT' named entity 'PATIENT' named entity 'THERAPEUTIC AGENT' named entity 'REGION' named entity 'ALTERATION' named entity 'EPITOPE' named entity 'APPROVED' named entity 'ANTIBODY LIBRARY' named entity 'ISOLATED' named entity 'REACTIVE' named entity 'CURRENTLY' named entity 'EXPERIMENTS' named entity 'PREDICT' named entity 'USING' named entity 'VIRUS' named entity 'STRAINS' named entity 'STEM' named entity 'DISPLAYED' named entity 'DOMAIN' named entity 'LINKER' named entity 'UNSTRUCTURED' named entity 'DAYS' named entity 'TREATMENT' named entity 'BINDS' named entity 'KOREA' named entity 'RECOMBINANT' named entity '90%' named entity 'MORE THAN' named entity 'CRITICAL' named entity 'LETHAL DOSE' named entity 'IN VIVO' named entity 'ANTIBODY' named entity 'JAPAN' named entity 'HB28' named entity 'PREVIOUSLY'

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