About: Tacrolimus trough levels before, during and after jejunostomy in a liver transplant patient: A case report

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tacrolimus trough levels before, during and after jejunostomy in a liver transplant patient: A case report
Creator	Charpiat, Bruno Ducerf, Christian Duperret, Serge Gazon, Mathieu Mabrut, Jean-Yves Mezoughi, Salim Preuss, Juliane Tod, Michel
Source	Elsevier; Medline; PMC
abstract	Although the feasibility of oral tacrolimus administration in the presence of jejunostomy has already been reported, few studies monitoring tacrolimus trough blood levels have been analyzed in detail, either during or after a jejunostomy closure. We report on our experience with a 34-year-old patient who underwent liver transplantations, with a proximal jejunostomy constructed a few days prior to the second transplantation. He was administered tacrolimus by a predominantly oral route, and less frequently received it by jejunostomy. The aim of this paper is to discuss this administration strategy and whether a different method could have been more suitable. This case report highlights that during the jejunostomy period, the tacrolimus doses that were required to maintain trough concentrations within the therapeutic range were four times higher than those administered after the closure of the jejunostomy. We observed an increase in the Dose-Normalized Trough Concentration (DNTC) values when tacrolimus was administered for 4 consecutive days by jejunostomy as compared to oral administration, indicating that the relative bioavailability of tacrolimus increased. Moreover, when returning to oral administration, the subsequent DNTC value was halved, highlighting a reduction in the tacrolimus bioavailability. Thus, in such a case, administration by jejunostomy could be more appropriate.
has issue date	2012-06-29(xsd:dateTime)
bibo:doi	10.1016/j.clinre.2012.05.011
bibo:pmid	22749693
has license	no-cc
sha1sum (hex)	048126d4fb5dd8205d6f5f5f67420c988f2b58e1
schema:url	https://doi.org/10.1016/j.clinre.2012.05.011
resource representing a document's title	Tacrolimus trough levels before, during and after jejunostomy in a liver transplant patient: A case report
has PubMed Central identifier	PMC7104052
has PubMed identifier	22749693
schema:publication	Clin Res Hepatol Gastroenterol
resource representing a document's body	covid:048126d4fb5dd8205d6f5f5f67420c988f2b58e1#body_text
is schema:about of	named entity 'oral administration' named entity 'jejunostomy' named entity 'tacrolimus' named entity 'liver' named entity 'case' named entity 'Trough' named entity 'detail' named entity 'jejunostomy' named entity 'jejunostomy' covid:arg/048126d4fb5dd8205d6f5f5f67420c988f2b58e1 named entity 'tacrolimus' named entity 'indicating' named entity 'compared' named entity 'blood' named entity 'highlights' named entity 'jejunostomy' named entity 'jejunostomy' named entity 'This' named entity 'Thus' named entity 'tacrolimus' named entity 'jejunostomy' named entity 'jejunostomy' named entity 'tacrolimus' named entity 'therapeutic range' named entity 'tacrolimus' named entity 'blood levels' named entity 'jejunostomy' named entity 'liver' named entity 'tacrolimus' named entity 'jejunostomy' named entity 'e127' named entity 'Tacrolimus' named entity 'Tacrolimus' named entity 'jejunostomy' named entity 'orally administered' named entity 'case reports' named entity 'CYP3A4' named entity 'fluconazole' named entity 'tacrolimus' named entity 'tacrolimus' named entity 'liver transplantation' named entity 'tacrolimus' named entity 'oral administration' named entity 'tacrolimus' named entity 'Tacrolimus' named entity 'tacrolimus' named entity 'isoenzymes' named entity 'tacrolimus' named entity 'drug interactions' named entity 'Immunosuppression' named entity 'renal function' named entity 'dialysis' named entity 'stoma' named entity 'first-pass metabolism' named entity 'gastrointestinal' named entity 'bioavailability' named entity 'blood transfusions' named entity 'liver function' named entity 'jejunostomy' named entity 'blood levels' named entity 'absolute bioavailability' named entity 'liver dysfunction' named entity 'liver transplantation' named entity 'oral route' named entity 'ng/mL' named entity 'parenteral' named entity 'Elsevier Masson' named entity 'lactic acid' named entity 'jejunostomy' named entity 'renal dysfunction' named entity 'therapeutic range' named entity 'oral dose' named entity 'stoma' named entity 'gastrointestinal'

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