About: Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis

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About: Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Creator	Nishimura, Hidekazu Ebina, Masahito Hisata, Shu Ishizaka, Akitoshi Maruyama, Ikuro Miyasho, Taku Nukiwa, Toshihiro Ohkouchi, Shinya Ohta, Hiromitsu Okada, Yoshinori Shibata, Naoko Takashi, Kondo Tamada, Tsutomu Taniguchi, Hiroyuki Yamada, Shingo
Source	Medline; PMC
abstract	The pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) remains to be elucidated. To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cytokines were measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF patients after the onset of acute exacerbation. HMGB1 gradually increased in the alveolar fluid after the onset of acute exacerbation, in positive correlation with monocytes chemotactic protein-1 (MCP-1), a potent fibrogenic mediator. In the lung tissues of eight IPF patients autopsied after acute exacerbation, intense cytoplasmic staining for HMGB1 was observed in the alveolar epithelial cells in alveolar capillary augmented lesions, where the capillary endothelial cells remarkably reduced the expression of thrombomodulin, an intrinsic antagonist of HMGB1. These results suggest pathogenic roles for HMGB1 and MCP-1 in the late phase of acute exacerbation of IPF.
has issue date	2011-02-21(xsd:dateTime)
bibo:doi	10.1155/2011/916486
bibo:pmid	21637372
has license	cc-by
sha1sum (hex)	049d68aa5279d807e4125c33a3d563f6df987cb4
schema:url	https://doi.org/10.1155/2011/916486
resource representing a document's title	Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis
has PubMed Central identifier	PMC3100576
has PubMed identifier	21637372
schema:publication	Pulm Med
resource representing a document's body	covid:049d68aa5279d807e4125c33a3d563f6df987cb4#body_text
is schema:about of	named entity 'serially' named entity 'alveolar' named entity 'acute exacerbation' named entity 'acute exacerbation' named entity 'chief' named entity 'idiopathic pulmonary fibrosis' named entity 'ONSET OF' covid:arg/049d68aa5279d807e4125c33a3d563f6df987cb4 named entity 'MEASURED' named entity 'MONOCYTES' named entity 'CONCENTRATIONS' named entity 'THROMBOMODULIN' named entity 'RESULTS' named entity 'CYTOPLASMIC STAINING' named entity 'LATE PHASE' named entity 'CAPILLARY' named entity 'EVALUATE' named entity 'INTENSE' named entity 'INFLAMMATORY MEDIATORS' named entity 'LESIONS' named entity 'CORRELATION' named entity 'WHERE' named entity 'ALVEOLAR' named entity 'PROTEIN' named entity 'CYTOKINES' named entity 'MCP-1' named entity 'PATHOGENIC' named entity 'IPF' named entity 'SUGGEST' named entity 'ROLES' named entity 'OBSERVED' named entity 'INCREASE' named entity 'PATHOGENESIS' named entity 'ALVEOLAR EPITHELIAL CELLS' named entity 'REDUCED' named entity 'PATIENTS' named entity 'HIGH MOBILITY GROUP PROTEIN B1' named entity 'ONSET OF' named entity 'LUNG TISSUES' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'INFLAMMATORY' named entity 'ALVEOLAR FLUID' named entity 'POSITIVE' named entity 'ANTAGONIST' named entity 'CAPILLARY ENDOTHELIAL CELLS' named entity 'SAMPLED' named entity 'INCREASED' named entity 'ACUTE LUNG INJURY' named entity 'THESE' named entity 'HMGB1' named entity 'SEVEN' named entity 'THE LUNGS' named entity 'GRADUAL' named entity 'EXPRESSION' named entity 'INTRINSIC' named entity 'HIGH MOBILITY GROUP PROTEIN B1' named entity 'MEDIATOR' named entity 'intrinsic' named entity 'cytoplasmic' named entity 'measured' named entity 'alveolar' named entity 'pathogenic' named entity 'alveolar' named entity 'Gradual' named entity 'staining' named entity 'MCP-1' named entity 'lung'

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