About: The antiviral and the coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?

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About: The antiviral and the coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The antiviral and the coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?
Creator	Isidoro, Ciro Fuzimoto, Andréa
Source	Elsevier; Medline; PMC
abstract	INTRODUCTION: As of March 11th, 2020, the World Health Organization declared the COVID-19 outbreak a pandemic. Articles published after the SARS-CoV-1 (2002) epidemic suggest that the use of an herbal-drug integrative medical approach could have contributed to a lower fatality rate and a more rapid response in controlling the outbreak. METHODS: Pubmed was searched for articles that investigated the antiviral properties and mechanisms of action of herbs or natural compounds against the SARS-coronavirus (CoV). RESULTS: Forty-three (43) relevant papers were located. A general count rendered 450+ herbs and natural compounds with antiviral properties against the SARS-CoV and related viruses. From the 43 articles, thirty-one (31) uncovered the mechanisms of action of the natural substances able to oppose the coronavirus. DISCUSSION: A series of herbs and natural compounds demonstrated moderate to strong antiviral activity. Research on many herbs-natural compounds also showed potent and significant inhibition of CoV-host protein pathways responsible for different phases of viral replication specifically targeting 3CL(PRO), PL(PRO), RdRp, helicase protein, S protein, N protein, 3a protein, Cathepsin L, Nsp1, Nsp3c, and ORF7a, and the S protein-ACE-2 interaction. CONCLUSION: The herbs-natural compounds with antiviral activity and that caused inhibition/blockade of the CoV-host protein pathways are potential therapeutic candidates. The homology between the SARS-CoV-1 and SARS-CoV-2 is around 80%. Thus, effective herbs-compounds for the former would likely be beneficial for the latter also depending on target protein similarities between the viruses. Here we provide the mechanistic bases supporting an integrative approach that includes natural compounds to fight coronavirus infections.
has issue date	2020-05-30(xsd:dateTime)
bibo:doi	10.1016/j.jtcme.2020.05.003
bibo:pmid	32691005
has license	no-cc
sha1sum (hex)	04ab166d407d318756232a5a73a4940938dba9a1
schema:url	https://doi.org/10.1016/j.jtcme.2020.05.003
resource representing a document's title	The antiviral and the coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?
has PubMed Central identifier	PMC7260130
has PubMed identifier	32691005
schema:publication	J Tradit Complement Med
resource representing a document's body	covid:04ab166d407d318756232a5a73a4940938dba9a1#body_text
is schema:about of	named entity 'HERBS' named entity 'coronavirus' named entity 'ANTIVIRAL' named entity 'ENDOSOME' named entity 'protein' named entity 'PROTEIN' named entity 'COVID-19 pandemic' named entity 'ACE-2' named entity 'CATHEPSIN' named entity 'PROTEIN' named entity 'coronavirus' named entity 'coronavirus' named entity 'antiviral' named entity 'TMPRSS2' named entity 'antiviral' named entity 'PROTEIN' named entity 'Spike protein' named entity 'Dengue' named entity 'SARS-CoV' named entity 'chlorogenic acid' named entity 'MERS-CoV' named entity 'TCM' named entity '10µM' named entity 'SARS-CoV' named entity 'preventive care' named entity 'inhibitory activity' named entity 'chrysophanol' named entity 'emodin' named entity 'Sophora' named entity 'motor proteins' named entity 'severe acute respiratory syndrome' named entity 'in-vitro' named entity 'drug discovery' named entity 'Cibotium barometz' named entity 'corticosteroids' named entity 'DNA helicases' named entity 'HCoV-NL63' named entity 'NF-κβ' named entity 'toxicity' named entity 'curcumin' named entity 'nonstructural proteins' named entity 'papain' named entity 'HCoV-OC43' named entity 'viral assembly' named entity 'antiviral activity' named entity 'IFN-α' named entity 'protein' named entity 'Isatis indigotica' named entity 'Hypericum perforatum' named entity 'RNA synthesis' named entity 'Pyrrosia lingua' named entity 'Paulownia tomentosa' named entity 'SARS' named entity 'SARS-CoV' named entity 'HCoV-OC43' named entity 'Houttuynia cordata' named entity 'quercitrin' named entity 'Traditional Chinese Medicine' named entity 'TCM' named entity 'ferruginol' named entity 'celastrol' named entity 'Pu'er' named entity 'SARS-CoV' named entity 'epicatechin' named entity 'azauridine' named entity 'Houttuynia cordata' named entity 'lab animals' named entity 'SARS' named entity 'transcription' named entity 'Houttuynia cordata' named entity 'productive cough' named entity 'antiviral' named entity 'virus' named entity 'Stephania tetrandra' named entity 'theophylline' named entity 'endosomes' named entity 'sinigrin' named entity 'antiviral activity' named entity 'monensin' named entity 'clinical presentation'

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