About: COVID-19–Related Collapsing Glomerulopathy in a Kidney Transplant Recipient

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About: COVID-19–Related Collapsing Glomerulopathy in a Kidney Transplant Recipient Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19–Related Collapsing Glomerulopathy in a Kidney Transplant Recipient
Creator	Pallet, Nicolas Binois, Yannick Bruneau, Thomas Karras, Alexandre Lazareth, Hélène Péré, Hélène Rabant, Marion Schurder, Juliet Thervet, Eric Veyer, David
source	Elsevier; Medline; PMC
abstract	We report a case of a kidney transplant recipient who presented with acute kidney injury and nephrotic-range proteinuria in a context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Kidney biopsy revealed collapsing glomerulopathy. Droplet-based digital PCR did not detect the presence of SARS-CoV-2 RNA in the biopsy fragment, and the virus was barely detectable in the plasma at the time of the biopsy. SARS-CoV-2 RNAemia peaked several days later, followed by a seroconversion despite the absence of circulating CD19-positive lymphocytes at admission due to rituximab-based treatment of antibody-mediated rejection 3 months earlier. Genotyping for the two risk alleles of the apolipoprotein L1 (APOL1) gene revealed that the donor carried the low-risk G0/G2 genotype. This case illustrates that COVID-19 may promote a collapsing glomerulopathy in kidney allografts with a low-risk APOL1 genotype, in the absence of detectable SARS-CoV2 RNA in the kidney, and that podocyte injury may precede SARS-CoV2 RNAemia.
has issue date	2020-07-12(xsd:dateTime)
bibo:doi	10.1053/j.ajkd.2020.06.009
bibo:pmid	32668317
has license	no-cc
sha1sum (hex)	04c7cc7215fe4e62c7a9c32e9b47eeb026defb14
schema:url	https://doi.org/10.1053/j.ajkd.2020.06.009
resource representing a document's title	COVID-19–Related Collapsing Glomerulopathy in a Kidney Transplant Recipient
has PubMed Central identifier	PMC7354772
has PubMed identifier	32668317
schema:publication	Am J Kidney Dis
resource representing a document's body	covid:04c7cc7215fe4e62c7a9c32e9b47eeb026defb14#body_text
is schema:about of	named entity 'µmol/L' named entity 'received a kidney' named entity 'coronavirus disease 2019' named entity 'nephrotic-range' named entity 'mycophenolate mofetil' named entity 'kidney transplant' named entity 'corticosteroids' named entity 'glomerulopathy' named entity 'SARS-CoV-2' named entity 'membrane proteins' named entity 'podocyte' named entity 'genetic background' named entity 'immunoassay' named entity 'prednisone' named entity 'allografts' named entity 'staining' named entity 'virus' named entity 'low molecular weight' named entity 'glomerulopathy' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'plasma' named entity 'RNA' named entity 'schistosome' named entity '5.8' named entity 'RNA' named entity 'kidney cells' named entity 'methylprednisolone' named entity 'microliter' named entity 'SARS-CoV-2' named entity 'protein' named entity 'kidney transplant' named entity 'vomiting' named entity 'polymerase chain reaction' named entity 'biopsy' named entity 'endogenous control' named entity 'follow-up' named entity 'RNA' named entity 'infection' named entity 'SARS-CoV-2' named entity 'β2-microglobulin' named entity 'APOL1' named entity 'tumor necrosis factor' named entity 'follow-up' named entity 'virus' named entity 'polyomavirus' named entity 'podocyte' named entity 'APOL1' named entity 'genotype' named entity 'second-hit' named entity 'rituximab' named entity 'sensitive and specific' named entity 'nucleic acids' named entity 'retinol binding protein' named entity 'allografts' named entity 'Evolution' named entity 'COVID' named entity 'brush border' named entity 'tacrolimus' named entity 'biopsy' named entity 'kidney function' named entity 'creatinine' named entity 'dimers' named entity 'podocyte' named entity 'glomerulonephritis' named entity 'prednisone' named entity 'hepatitis' named entity 'SARS-CoV-2' named entity 'proteinuria' named entity 'kidney disease' named entity 'viremia' named entity 'homeostasis'

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