About: Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases

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About: Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases
Creator	Nagao, Yumiko Sata, Michio Hashimoto, Kouji
Source	Medline; PMC
abstract	BACKGROUND: Oral lichen planus (OLP) is seen frequently in patients with hepatitis C virus (HCV) infection. The aim of this study was to evaluate the occurrence of oral candidiasis, other mucosal lesions, and xerostomia during interferon (IFN) therapy for HCV infection. METHODS: Of 124 patients with HCV-infected liver diseases treated with IFN therapy in our hospital, 14 (mean age 56.00 ± 12.94 years) who attended to receive administration of IFN once a week were identified and examined for Candida infection and other oral lesions and for the measurement of salivary flow. Serological assays also were carried out. RESULTS: Cultures of Candida from the tongue surfaces were positive in 7 (50.0%) of the 14 patients with HCV infection at least once during IFN therapy. C. albicans was the most common species isolated. The incidence of Candida during treatment with IFN did not increase above that before treatment. Additional oral mucosal lesions were observed in 50.0% (7/14) of patients: OLP in three (21.4%), angular cheilitis in three (21.4%) and recurrent aphthous stomatitis in one (7.1%). OLP occurred in one patient before treatment with IFN, in one during treatment and in one at the end of treatment. 85.7% of the oral lesions were treated with topical steroids. We compared the characteristics of the 7 patients in whom Candida was detected at least once during IFN therapy (group 1) and the 7 patients in whom Candida was not detected during IFN therapy (group 2). The prevalence of oral mucosal lesions (P=0.0075) and incidence of external use of steroids (P=0.0308) in group 1 were significantly higher than in group 2. The average body weight of group 1 decreased significantly compared to group 2 (P=0.0088). Salivary flow decreased in all subjects throughout the course of IFN treatment and returned at 6(th) months after the end of treatment. In group 1, the level of albumin at the beginning of the 6(th) month of IFN administration was lower than in group 2 (P=0.0550). According to multivariate analysis, one factor, the presence of oral mucosal lesions, was associated with the detection of Candida. The adjusted odds ratio for the factor was 36.00 (95% confidence interval 2.68-1485.94). CONCLUSION: We should pay more attention to oral candidiasis as well as other oral mucosal lesions, in patients with weight loss during IFN treatment.
has issue date	2012-11-02(xsd:dateTime)
bibo:doi	10.1186/1471-230x-12-155
bibo:pmid	23122361
has license	cc-by
sha1sum (hex)	04c80346278c76be38e11fba9ee1a0fccc13c57f
schema:url	https://doi.org/10.1186/1471-230x-12-155
resource representing a document's title	Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases
has PubMed Central identifier	PMC3503792
has PubMed identifier	23122361
schema:publication	BMC Gastroenterol
resource representing a document's body	covid:04c80346278c76be38e11fba9ee1a0fccc13c57f#body_text
is schema:about of	named entity 'CHRONIC' named entity 'carried' named entity 'Serological' named entity 'patients' named entity 'identified' named entity 'IFN' named entity 'therapy' named entity 'LIVER DISEASES' named entity 'OCCURRENCE' named entity 'ATTENDED' named entity 'STUDY' named entity 'THERAPY' named entity 'CANDIDA INFECTION' named entity 'METHODS' named entity 'MUCOSAL LESIONS' named entity 'HCV INFECTION' named entity 'SEEN' named entity 'EXAMINED FOR' named entity 'HCV' named entity 'ONCE A WEEK' named entity 'CARRIED' named entity 'YEARS' named entity 'CANDIDIASIS' named entity 'RELATED' named entity 'INTERFERON THERAPY' named entity 'ORAL LESIONS' named entity 'ORAL CANDIDIASIS' named entity 'FREQUENTLY' named entity 'BACKGROUND' named entity 'TREATED WITH' named entity 'RECEIVE' named entity 'SEROLOGICAL' named entity 'EVALUATE' named entity 'ORAL LICHEN PLANUS' named entity 'INFECTION' named entity 'OUR' named entity 'INFECTED' named entity 'ADMINISTRATION' named entity 'HOSPITAL' named entity 'AGE' named entity 'INTERFERON ' named entity 'IDENTIFIED' named entity 'HEPATITIS C VIRUS' named entity 'IFN' named entity 'MEASUREMENT' named entity 'XEROSTOMIA' named entity 'LIVER DISEASES' named entity 'SALIVARY' named entity 'AIM' named entity 'PATIENTS' named entity 'ORAL MUCOSAL LESIONS' named entity '124' named entity 'FLOW' named entity 'HCV' covid:arg/04c80346278c76be38e11fba9ee1a0fccc13c57f named entity 'xerostomia' named entity 'infection' named entity 'HCV' named entity 'infection' named entity 'Oral lichen planus' named entity 'Serological' named entity 'HCV' named entity 'dental caries' named entity 'genotype' named entity 'IFN' named entity 'radiologists' named entity 'HCV' named entity 'Xerostomia' named entity 'infection' named entity 'C. albicans' named entity 'HCV' named entity 'HCV' named entity 'yeast infection' named entity 'secretion' named entity 'infection' named entity 'Phase III trial' named entity 'adverse events' named entity 'salivary gland' named entity 'HCV'

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