About: Evaluation of the Luminex xTAG Respiratory Viral Panel FAST v2 assay for detection of multiple respiratory viral pathogens in nasal and throat swabs in Vietnam

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About: Evaluation of the Luminex xTAG Respiratory Viral Panel FAST v2 assay for detection of multiple respiratory viral pathogens in nasal and throat swabs in Vietnam Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of the Luminex xTAG Respiratory Viral Panel FAST v2 assay for detection of multiple respiratory viral pathogens in nasal and throat swabs in Vietnam
Creator	Hoa, Khanh Hospital, General Nguyen, Van Phuc, Tran Tan, H Thi, Nguyen Tran, Anh Baker, Le Dang, Thao Dang, Trung Dong, Nhu Hang, Ty Hien, Maia Hiep, Nguyen Hospital, Hoa Huong, Ho Khanh, Vietnam Nghia, Nguyen Ny, Han Phuong, Rabaa, Guy Rogier Van Doorn, Tam, Thanh Thap, Dong Thi, Hong Thi, Pham Thi, Vu Thwaites, Stephen Van Hung, Tran Vu, Pham Xang, Nguyen
Source	Medline; PMC
abstract	Background: Acute respiratory infections (ARI) are among the leading causes of hospitalization in children ≤5 years old. Rapid diagnostics of viral pathogens is essential to avoid unnecessary antibiotic treatment, thereby slowing down antibiotic-resistance. We evaluated the diagnostic performance of the Luminex xTAG Respiratory Viral Panel FAST v2 against viral specific PCR as reference assays for ARI in Vietnam. Methods: Four hundred and forty two nose and throat swabs were collected in viral transport medium, and were tested with Luminex xTAG Respiratory Viral Panel FAST v2. Multiplex RT-PCR and single RT-PCR were used as references. Results: Overall, sensitivity of the Luminex against reference assays was 91.8%, 95% CI 88.1-94.7 (270/294), whilst 112/6336 (1.8%, 95% CI, 1.4-2.1) of pathogens were detected by the Luminex, but not by reference assays. Frequency of pathogens detected by Luminex and reference assays was 379 and 292, respectively. The diagnostic yield was 66.7% (295/442, 95%CI 62.1-71.1%) for the Luminex assay and 54.1% (239/442, 95% CI, 49.3-58.8%) for reference assays. The Luminex kit had higher yields for all viruses except influenza B virus, respiratory syncytial virus, and human bocavirus. High agreements between both methods [mean (range): 0.91 (0.83-1.00)] were found for 10/15 viral agents. Conclusions: The Luminex assay is a high throughput multiplex platform for rapid detection of common viral pathogens causing ARI. Although the current high cost may prevent Luminex assays from being widely used, especially in limited resource settings where ARI are felt most, its introduction in clinical diagnostics may help reduce unnecessary use of antibiotic prescription.
has issue date	2018-04-30(xsd:dateTime)
bibo:doi	10.12688/wellcomeopenres.12429.2
bibo:pmid	29503874
has license	cc-by
sha1sum (hex)	04d638b3c1d8b8fcd771e569e439b364d4ac2c1a
schema:url	https://doi.org/10.12688/wellcomeopenres.12429.2
resource representing a document's title	Evaluation of the Luminex xTAG Respiratory Viral Panel FAST v2 assay for detection of multiple respiratory viral pathogens in nasal and throat swabs in Vietnam
has PubMed Central identifier	PMC5811805
has PubMed identifier	29503874
schema:publication	Wellcome Open Res
resource representing a document's body	covid:04d638b3c1d8b8fcd771e569e439b364d4ac2c1a#body_text
is schema:about of	named entity 'Respiratory' named entity 'swabs' named entity 'Vietnam' named entity 'LUMINEX' named entity 'RESPIRATORY' named entity 'DETECTION' named entity 'SWABS' named entity 'ARI' named entity 'A45' named entity 'REFERENCE' named entity 'VIETNAM' named entity 'YEARS' named entity 'RAPID' named entity 'SLOWING' named entity 'BACKGROUND' named entity 'ESSENTIAL' named entity 'DIAGNOSTICS' named entity 'CHILDREN' named entity 'SPECIFIC' named entity 'PCR' named entity 'RESPIRATORY VIRAL PANEL' named entity 'VIETNAM' named entity 'EVALUATION' named entity 'VIRAL' named entity 'ANTIBIOTIC TREATMENT' named entity 'RESPIRATORY VIRAL PANEL' named entity 'OPEN' named entity 'FAST' named entity 'MULTIPLE' named entity 'PEER REVIEW' named entity 'THROAT' named entity 'VIRAL PATHOGENS' named entity 'FAST' named entity 'LUMINEX' named entity 'EVALUATED' named entity 'DIAGNOSTIC' named entity 'PERFORMANCE' named entity 'APPROVED' named entity 'HOSPITALIZATION' named entity 'VIRAL PATHOGENS' named entity 'TO AVOID' named entity 'NASAL' named entity 'ASSAY' named entity 'OLD' named entity 'CAUSES' named entity 'LEADING' named entity 'ANTIBIOTIC-RESISTANCE' named entity 'ACUTE RESPIRATORY INFECTIONS' covid:arg/04d638b3c1d8b8fcd771e569e439b364d4ac2c1a named entity 'respiratory infections' named entity 'hospitalization'

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