About: Clinical and Molecular Epidemiology of Human Rhinovirus Infections in Patients with Hematologic Malignancy

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About: Clinical and Molecular Epidemiology of Human Rhinovirus Infections in Patients with Hematologic Malignancy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical and Molecular Epidemiology of Human Rhinovirus Infections in Patients with Hematologic Malignancy
Creator	Lamson, Daryl Shore, Tsiporah George, Guzman, Brigitte Jacobs, Samantha Jenkins, Stephen Leonard, John Ritchie, Ellen Satlin, Michael Schuetz, Audrey Soave, Rosemary St, Kirsten Van Besien, Koen Walsh, Thomas Zappetti, Dana
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Human rhinoviruses (HRVs) are common causes of upper respiratory tract infection (URTI) in hematologic malignancy (HM) patients. Predictors of lower respiratory tract infection (LRTI) including the impact of HRV species and types are poorly understood. OBJECTIVES: This study aims to describe the clinical and molecular epidemiology of HRV infections among HM patients. STUDY DESIGN: From April 2012–March 2013, HRV-positive respiratory specimens from symptomatic HM patients were molecularly characterized by analysis of partial viral protein 1 (VP1) or VP4 gene sequence. HRV LRTI risk-factors and outcomes were analyzed using multivariable logistic regression. RESULTS: One hundred and ten HM patients presented with HRV URTI (n=78) and HRV LRTI (n=32). Hypoalbuminemia (OR 3.0; 95% CI, 1.0 – 9.2; p=0.05) was independently associated with LRTI, but other clinical and laboratory markers of host immunity did not differ between patients with URTI versus LRTI. Detection of bacterial co-pathogens was common in LRTI cases (25%). Among 92 typeable respiratory specimens, there were 58 (64%) HRV-As, 12 (13%) HRV-Bs, and 21 (23%) HRV-Cs, and one Enterovirus 68. LRTI rates among HRV-A (29%), HRV-B (17%), and HRV-C (29%) were similar. HRV-A infections occurred year-round while HRV-B and HRV-C infections clustered in the late fall and winter. CONCLUSIONS: HRVs are associated with LRTI in HM patients. Illness severity is not attributable to specific HRV species or types. The frequent detection of bacterial co-pathogens in HRV LRTIs further substantiates the hypothesis that HRVs predispose to bacterial superinfection of the lower airways, similar to that of other community-acquired respiratory viruses.
has issue date	2015-10-01(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2015.07.309
bibo:pmid	26370315
has license	green-oa
sha1sum (hex)	051382aee4c0ba273ffcecaa0ec1b3bf28a3c3a7
schema:url	https://doi.org/10.1016/j.jcv.2015.07.309
resource representing a document's title	Clinical and Molecular Epidemiology of Human Rhinovirus Infections in Patients with Hematologic Malignancy
has PubMed Central identifier	PMC4750469
has PubMed identifier	26370315
schema:publication	Journal of Clinical Virology
resource representing a document's body	covid:051382aee4c0ba273ffcecaa0ec1b3bf28a3c3a7#body_text
is schema:about of	named entity 'INFECTIONS' named entity 'TYPES' named entity 'HUMAN' named entity 'RHINOVIRUSES' covid:arg/051382aee4c0ba273ffcecaa0ec1b3bf28a3c3a7 named entity 'PATIENTS' named entity 'HEMATOLOGIC MALIGNANCY' named entity 'MOLECULAR EPIDEMIOLOGY' named entity 'BACKGROUND' named entity 'COMMON' named entity 'SPECIES' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'IMPACT' named entity 'UNDERSTOOD' named entity 'HEMATOLOGIC MALIGNANCY' named entity 'CAUSES' named entity 'POORLY' named entity 'UPPER RESPIRATORY TRACT INFECTION' named entity 'HRV' named entity 'INCLUDING' named entity 'CLINICAL' named entity 'HUMAN RHINOVIRUS' named entity 'PATIENTS' named entity 'molecular epidemiology' named entity 'epithelial cells' named entity 'molecular testing' named entity 'HRV' named entity 'confounder' named entity 'statistical power' named entity 'bioMérieux' named entity 'HRV' named entity 'LRTI' named entity 'WCMC' named entity 'LRTI' named entity 'virus' named entity 'DFA' named entity 'follow-up' named entity 'HSCT' named entity 'HRV' named entity 'infection' named entity 'fever' named entity 'HRV' named entity 'HRV' named entity 'Institutional Review Boards' named entity 'LRTI' named entity 'HRV' named entity 'HRV' named entity 'phylogenetic tree' named entity 'HRV' named entity 'Emerging Infectious Diseases' named entity 'GVHD' named entity 'HRV' named entity 'HRV' named entity 'direct fluorescent antibody' named entity 'LRTI' named entity 'serotypes' named entity 'pathogens' named entity 'risk factors' named entity 'HRV' named entity 'HRV' named entity 'cytokine' named entity 'Pediatric' named entity 'HRV' named entity 'social distancing' named entity 'HRV' named entity 'intensive care unit' named entity 'asthma'

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