About: Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer's dementia

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About: Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer's dementia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer's dementia
Creator	Andersen, K Lolk, A Nielsen, R.-E Rodrigo-Domingo, M Valentin, J.-B
Source	Elsevier; Medline; PMC
abstract	Abstract Background Alzheimer's disease (AD), the most common disease causing dementia, is linked to increased mortality. However, the effect of antipsychotic use on specific causes of mortality has not yet been investigated thoroughly. Methods Utilizing the Danish nationwide registers, we defined a cohort of patients diagnosed with AD. Utilizing separate Cox regressions for specific causes of mortality, we investigated the effects of cumulative antipsychotic dosage after diagnosis and current antipsychotic exposure in the time period 2000–2011. Results In total, 45,894 patients were followed for 3,803,996 person-years. A total of 6129 cardiovascular related deaths, 2088 cancer related deaths, 1620 infection related deaths, and 28 intentional self-harm related deaths are presented. Current antipsychotic exposure increased mortality rate with HR between 1.92 and 2.31 for cardiovascular, cancer, and infection related death. Cumulative antipsychotic dosages were most commonly associated with increased rates of mortality for cardiovascular and infection as cause of death, whereas the associations were less clear with cancer and intentional self-harm as cause of death. Conclusions We showed that cumulative antipsychotic drug dosages increased mortality rates for cardiovascular and infection as cause of death. These findings highlight the need for further investigations of long-term effects of treatment and of possible sub-groups who could benefit from treatment.
has issue date	2017-05-31(xsd:dateTime)
bibo:doi	10.1016/j.eurpsy.2016.11.013
bibo:pmid	28199869
has license	els-covid
sha1sum (hex)	0532e2b4ab8406ffee6537f39921c8197fe373ce
schema:url	https://doi.org/10.1016/j.eurpsy.2016.11.013
resource representing a document's title	Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer's dementia
has PubMed Central identifier	PMC7126709
has PubMed identifier	28199869
schema:publication	European Psychiatry
resource representing a document's body	covid:0532e2b4ab8406ffee6537f39921c8197fe373ce#body_text
is schema:about of	named entity 'INFECTION' named entity 'DEMENTIA' named entity '27S' named entity 'CAUSE OF DEATH' named entity 'EFFECTS' named entity 'ALZHEIMER' named entity 'ANTIPSYCHOTIC TREATMENT' named entity 'PATIENTS' named entity 'INTENTIONAL SELF-HARM' named entity 'CANCER' named entity 'CARDIOVASCULAR' named entity 'treatment effects' named entity 'antipsychotics' named entity 'risk of death' named entity 'antipsychotic drugs' named entity 'Female gender' named entity 'cardiovascular' named entity 'outpatient' named entity 'explanatory variable' named entity 'antipsychotics' named entity 'somatic' named entity 'antipsychotic drug' named entity '0.80' named entity 'outpatient' named entity '95% CI' named entity 'rate of mortality' named entity 'all-cause mortality' named entity 'antipsychotic' named entity 'dementia' named entity 'cardiovascular' named entity 'blood pressure' named entity 'mortality rate' named entity 'dementia' named entity 'Danish' named entity 'rate of mortality' named entity 'self-harm' named entity 'rate of mortality' named entity 'antipsychotic' named entity 'self-harm' named entity 'cardiovascular' named entity 'affective disorders' named entity 'rate of mortality' named entity 'mortality rate' named entity 'insulin' named entity 'HR 2' named entity 'psychiatric disorders' named entity 'follow-up' named entity 'antipsychotic' named entity 'Antipsychotics' named entity 'dependent variables' named entity 'survival bias' named entity 'antipsychotic' named entity 'antipsychotic' named entity 'DDDs' named entity 'Stata' named entity 'Danish' named entity 'co-morbidity' named entity 'antipsychotic drug' named entity 'increased cholesterol' named entity 'antipsychotic drugs' named entity 'DDDs' named entity 'Danish' named entity 'follow-up' named entity '0.80' named entity 'ICD-10' named entity 'type II diabetes' named entity 'drug treatment' named entity 'Alzheimer's disease' named entity 'outpatient' named entity '0.80' named entity 'self-harm' named entity '95% CI' named entity 'mortality rate' named entity 'antipsychotic' named entity 'cardiovascular events' named entity 'retrospective cohort study' named entity 'co-morbidities'

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