About: Immune Biomarkers Predictive of Respiratory Viral Infection in Elderly Nursing Home Residents

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About: Immune Biomarkers Predictive of Respiratory Viral Infection in Elderly Nursing Home Residents Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune Biomarkers Predictive of Respiratory Viral Infection in Elderly Nursing Home Residents
Creator	Botelho, F Johnstone, J Mcneil, S Millar, J Parsons, R
topic	covid:05445d95af0648219e8eb051ab3015b2a4615027#this
Source	Medline; PMC
abstract	OBJECTIVE: To determine if immune phenotypes associated with immunosenescence predict risk of respiratory viral infection in elderly nursing home residents. METHODS: Residents ≥65 years from 32 nursing homes in 4 Canadian cities were enrolled in Fall 2009, 2010 and 2011, and followed for one influenza season. Following influenza vaccination, peripheral blood mononuclear cells (PBMCs) were obtained and analysed by flow cytometry for T-regs, CD4+ and CD8+ T-cell subsets (CCR7+CD45RA+, CCR7-CD45RA+ and CD28-CD57+) and CMV-reactive CD4+ and CD8+ T-cells. Nasopharyngeal swabs were obtained and tested for viruses in symptomatic residents. A Cox proportional hazards model adjusted for age, sex and frailty, determined the relationship between immune phenotypes and time to viral infection. RESULTS: 1072 residents were enrolled; median age 86 years and 72% female. 269 swabs were obtained, 87 were positive for virus: influenza (24%), RSV (14%), coronavirus (32%), rhinovirus (17%), human metapneumovirus (9%) and parainfluenza (5%). In multivariable analysis, high T-reg% (HR 0.41, 95% CI 0.20–0.81) and high CMV-reactive CD4+ T-cell% (HR 1.69, 95% CI 1.03–2.78) were predictive of respiratory viral infection. CONCLUSIONS: In elderly nursing home residents, high CMV-reactive CD4+ T-cells were associated with an increased risk and high T-regs were associated with a reduced risk of respiratory viral infection.
has issue date	2014-10-02(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0108481
bibo:pmid	25275464
has license	cc-by
sha1sum (hex)	05445d95af0648219e8eb051ab3015b2a4615027
schema:url	https://doi.org/10.1371/journal.pone.0108481
resource representing a document's title	Immune Biomarkers Predictive of Respiratory Viral Infection in Elderly Nursing Home Residents
has PubMed Central identifier	PMC4183538
has PubMed identifier	25275464
schema:publication	PLoS One
resource representing a document's body	covid:05445d95af0648219e8eb051ab3015b2a4615027#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/05445d95af0648219e8eb051ab3015b2a4615027
is schema:about of	covid:arg/05445d95af0648219e8eb051ab3015b2a4615027 named entity 'phenotypes' named entity 'nursing homes' named entity 'influenza vaccine' named entity 'T-cell' named entity 'comorbidity' named entity 'CCR7' named entity 'active surveillance' named entity 'influenza season' named entity 'cytokine' named entity 'CD4+ T cells' named entity 'nutritional status' named entity 'infection' named entity 'CMV' named entity 'Lymphocytes' named entity 'CD8+' named entity 'influenza season' named entity 'PBMCs' named entity 'phenotypes' named entity 'headache' named entity 'nasal congestion' named entity 'virus' named entity 'T-regs' named entity 'infection' named entity 'T-regs' named entity 'TNF-a' named entity 'TNF' named entity 'CMV' named entity 'antibodies' named entity 'T-regs' named entity 'CMV' named entity 'Antibody staining' named entity 'immune cell' named entity 'sample size' named entity 'infection' named entity 'viral infection' named entity 'murine' named entity 'Genome Sciences' named entity 'T-regs' named entity 'CD4+ T cells' named entity 'virus infection' named entity 'infection' named entity '21 days' named entity 'CD8+ T-cells' named entity 'negative control' named entity 'PBMCs' named entity 'influenza vaccination' named entity 'CD8+ T-cell' named entity 'cognitive decline' named entity 'CD4+ T-cells' named entity 'T-reg' named entity 'viruses' named entity 'Toronto' named entity 'state variable' named entity 'Cox proportional hazards model' named entity 'immunosenescence' named entity 'CD8+' named entity 'immunosenescence' named entity 'confounder' named entity 'PBMCs' named entity 'high-risk' named entity 'coronavirus' named entity 'chi-square test' named entity 'senescent' named entity 'Beckman Coulter' named entity '1.03' named entity 'BD Biosciences' named entity 'CD127' named entity 'virus' named entity '1.10' named entity 'CCR7' named entity 'confidence intervals' named entity 'phenotypes' named entity 'antigenic' named entity 'nursing homes'

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