About: Comparison of nonhuman primates identified the suitable model for COVID-19

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Comparison of nonhuman primates identified the suitable model for COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comparison of nonhuman primates identified the suitable model for COVID-19
Creator	Ke, Changwen Li, Haiyan Yang, Jing Zhang, Yong Liu, Hongqi Yang, Yun Zheng, Huanying Peng, Xiaozhong Li, Jingmei Hu, Yunzhang Wang, Haixuan Dai, Qing Ding, Kaiyun Dong, Yinliang Gao, Jiahong Jiao, Li Kuang, Dexuan Lin, Xiaochen Liu, Yuqin Long, Haiting Lu, Shuaiyao Luo, Fangyu Ma, Chunxia Qian, Xingli Sun, Qiangming Wang, Junbin Wu, Daoju Xu, Jingwen Yang, Mengli Yu, Wenhai Zhao, Yuan Zhao, Siwen Zheng, Yinqiu Zhou, Jingxian
source	Medline; PMC
abstract	Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeys Macaca mulatta (M. mulatta) and Macaca fascicularis (M. fascicularis) and New World monkey Callithrix jacchus (C. jacchus). Infected M. mulatta and M. fascicularis showed abnormal chest radiographs, an increased body temperature and a decreased body weight. Viral genomes were detected in swab and blood samples from all animals. Viral load was detected in the pulmonary tissues of M. mulatta and M. fascicularis but not C. jacchus. Furthermore, among the three animal species, M. mulatta showed the strongest response to SARS-CoV-2, including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues. Collectively, these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M. mulatta as the most suitable for modeling COVID-19.
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1038/s41392-020-00269-6
bibo:pmid	32814760
has license	cc-by
sha1sum (hex)	057185bf9ec110e1c057b5d815f9c2aa1469bc43
schema:url	https://doi.org/10.1038/s41392-020-00269-6
resource representing a document's title	Comparison of nonhuman primates identified the suitable model for COVID-19
has PubMed Central identifier	PMC7434851
has PubMed identifier	32814760
schema:publication	Signal Transduct Target Ther
resource representing a document's body	covid:057185bf9ec110e1c057b5d815f9c2aa1469bc43#body_text
is schema:about of	named entity 'mulatta' named entity 'severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'remains' named entity 'response' named entity 'NEW WORLD MONKEY' named entity 'GENOMES' named entity 'INFECTED' named entity 'NONHUMAN PRIMATE' named entity 'TISSUES' named entity 'ABNORMAL CHEST' named entity 'ANIMAL SPECIES' named entity 'CYTOKINE EXPRESSION' named entity 'OLD WORLD MONKEYS' named entity 'VIRAL LOAD' named entity 'THESE' named entity 'NHP' named entity 'SUSCEPTIBILITIES' named entity 'IDENTIFICATION' named entity 'VIRAL' named entity 'MODEL OF' named entity 'SPECIES' named entity 'blood samples' named entity 'detected' named entity 'Callithrix jacchus' named entity 'pulmonary' named entity 'animal' named entity 'Macaca mulatta' named entity 'COVID-19' named entity 'M. fascicularis' named entity 'COVID' named entity 'Macaca mulatta' named entity 'Macaca fascicularis' named entity 'SARS-CoV-2' named entity 'rectum' named entity '37°C' named entity 'tissue samples' named entity 'lung' named entity 'necrotic' named entity 'viral RNA' named entity 'virus' named entity 'cytokines' named entity 'Medical Sciences' named entity 'virus' named entity 'virus' named entity 'NHP model' named entity 'RBC' named entity 'amino acids' named entity 'public health'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software