About: Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance

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About: Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance
Creator	Harper, James Miller, Richard Buehner, Gretchen Chang, Yayi Sigler, Robert Smith-Wheelock, Michael
Source	Medline; PMC
abstract	A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine‐deficient (Meth‐R) diet also increases maximal lifespan in (BALB/cJ × C57BL/6 J)F1 mice. Compared with controls, Meth‐R mice have significantly lower levels of serum IGF‐I, insulin, glucose and thyroid hormone. Meth‐R mice also have higher levels of liver mRNA for MIF (macrophage migration inhibition factor), known to be higher in several other mouse models of extended longevity. Meth‐R mice are significantly slower to develop lens turbidity and to show age‐related changes in T‐cell subsets. They are also dramatically more resistant to oxidative liver cell injury induced by injection of toxic doses of acetaminophen. The spectrum of terminal illnesses in the Meth‐R group is similar to that seen in control mice. Studies of the cellular and molecular biology of methionine‐deprived mice may, in parallel to studies of calorie‐restricted mice, provide insights into the way in which nutritional factors modulate longevity and late‐life illnesses.
has issue date	2005-04-13(xsd:dateTime)
bibo:doi	10.1111/j.1474-9726.2005.00152.x
bibo:pmid	15924568
has license	no-cc
sha1sum (hex)	0576f0ea34d99a7436f43deae3bac177f394e36f
schema:url	https://doi.org/10.1111/j.1474-9726.2005.00152.x
resource representing a document's title	Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance
has PubMed Central identifier	PMC7159399
has PubMed identifier	15924568
schema:publication	Aging Cell
resource representing a document's body	covid:0576f0ea34d99a7436f43deae3bac177f394e36f#body_text
is schema:about of	named entity 'The spectrum' named entity 'subsets' named entity 'induced' named entity 'modulate' named entity 'illnesses' named entity 'stress' named entity 'ACETAMINOPHEN' named entity 'HAVE' named entity 'MOUSE MODELS' named entity 'HERE' named entity 'LIVER CELL' named entity 'GROUP' named entity 'RATS' named entity 'MIGRATION INHIBITION FACTOR' named entity 'PROVIDE' named entity 'T-CELL SUBSETS' named entity 'CONTROLS' named entity 'LIVER' named entity 'REPORT' named entity 'CALORIE' named entity 'RELATED' named entity 'MODULATE' named entity 'INDUCED' named entity 'OXIDATIVE' named entity 'AGE' named entity 'PREVIOUSLY' named entity 'injury' named entity 'inbred' named entity 'macrophage' named entity 'doses' named entity 'glucose' named entity 'Meth' named entity 'calorie-restricted' named entity 'terminal illnesses' named entity 'liver' named entity 'serum' named entity 'IGF-I' named entity 'mice' named entity 'histiocytic sarcoma' named entity 'rat' named entity 'mouse strain' named entity 'disease processes' named entity 'RNA' named entity 'glucose' named entity 'oxidation' named entity 'amino acids' named entity 'hepatic' named entity 'amino acids' named entity 'mice' named entity 'thyroxine' named entity 'mice' named entity 'cellulose' named entity 'mice' named entity 'array-based' named entity 'ethanol' named entity 'liver' named entity 'Serum' named entity 'mice' named entity 'NADH' named entity 'mice' named entity 'mice' named entity 'Bar Harbor' named entity 'pathogenesis' named entity 'hepatic' named entity 'inanition' named entity 'pathogen' named entity 'glucocorticoids' named entity 'IGF-I' named entity 'St. Charles, MO' named entity 'biogerontology' named entity 'tyrosine' named entity 'tryptophan' named entity 'study population' named entity 'young adult' named entity 'cataract' named entity 'methionine'

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