About: A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III
Creator	Prabakaran, Ponraj Li, Wei Wu, Yanling Zhu, Zhongyu Cardosa, Jane Deng, Yongqiang Feng, Yang Hu, Dan Lei, Cheng Li, Shun Qin, Chengfeng Tian, Xiaolong Wang, Chunyu Wang, Yulu Zhang, Nana Zou, Peng Deng, S Dimitrov, Dimiter Li, Zhu Puriid, Vinita Yingid, Tianlei Zhang, Wu Zhaoid, Qi Zhouid, Xiaohui
Source	Medline; PMC
abstract	Dengue is the most widespread vector-borne viral disease caused by dengue virus (DENV) for which there are no safe, effective drugs approved for clinical use. Here, by using sequential antigen panning of a yeast antibody library derived from healthy donors against the DENV envelop protein domain III (DIII) combined with depletion by an entry defective DIII mutant, we identified a cross-reactive human monoclonal antibody (mAb), m366.6, which bound with high affinity to DENV DIII from all four DENV serotypes. Immunogenetic analysis indicated that m366.6 is a germline-like mAb with very few somatic mutations from the closest VH and Vλ germline genes. Importantly, we demonstrated that it potently neutralized DENV both in vitro and in the mouse models of DENV infection without detectable antibody-dependent enhancement (ADE) effect. The epitope of m366.6 was mapped to the highly conserved regions on DIII, which may guide the design of effective dengue vaccine immunogens. Furthermore, as the first germline-like mAb derived from a naïve antibody library that could neutralize all four DENV serotypes, the m366.6 can be a tool for exploring mechanisms of DENV infection, and is a promising therapeutic candidate.
has issue date	2019-06-26(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1007836
bibo:pmid	31242272
has license	cc0
sha1sum (hex)	057a931d8bfabff534eddd75a96af84a1b6b3deb
schema:url	https://doi.org/10.1371/journal.ppat.1007836
resource representing a document's title	A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III
has PubMed Central identifier	PMC6615639
has PubMed identifier	31242272
schema:publication	PLoS Pathog
resource representing a document's body	covid:057a931d8bfabff534eddd75a96af84a1b6b3deb#body_text
is schema:about of	named entity 'highly' named entity 'library' named entity 'bound' named entity 'epitope' named entity 'derived' named entity 'exploring' named entity 'monoclonal antibody' named entity 'ACCESS' named entity 'MONOCLONAL ANTIBODY' named entity 'MAB' named entity 'SEROTYPES' named entity 'IN VITRO' named entity 'COMBINED' named entity 'DIII' named entity 'DEPLETION' named entity 'AFFINITY' named entity 'CONSERVED' named entity 'INFECTION' named entity 'ANTIGEN' named entity 'VIRUS ENVELOPE' named entity 'PROTEIN DOMAIN' named entity 'MOUSE MODELS' named entity 'IMMUNOGENETIC' named entity 'ANALYSIS' named entity 'HUMAN' named entity 'IS A' named entity 'CAUSED BY' named entity 'DONORS' named entity 'WIDESPREAD' named entity 'GUIDE' named entity 'CANDIDATE' named entity 'DETECTABLE' named entity 'DERIVED' named entity 'TOOL' named entity 'DEFECTIVE' named entity 'MECHANISMS' named entity 'USING' named entity 'GERMLINE' named entity 'YEAST ANTIBODY' named entity 'HEALTHY' named entity 'LIKE' named entity 'IDENTIFIED' named entity 'CROSS-REACTIVE' named entity 'MAPPED' named entity 'DESIGN' named entity 'EXPLORING' named entity 'DENGUE' named entity 'USE' named entity 'GERMLINE' named entity 'BOUND' named entity 'IMMUNOGENS' named entity 'III' named entity 'HUMAN' named entity 'DENGUE VIRUS' named entity 'SOMATIC MUTATIONS' named entity 'CLINICAL' named entity 'APPROVED' named entity 'PANNING'

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