About: Development of a Rapid Fluorescent Immunochromatographic Test to Detect Respiratory Syncytial Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Development of a Rapid Fluorescent Immunochromatographic Test to Detect Respiratory Syncytial Virus
Creator	Park, Hyun Choi, Du-Young Yeo, Seon-Ju Yu, Seung-Taek Tuong, Hien Thi, Trinh Tien, Thuy
source	Medline; PMC
abstract	Human respiratory syncytial virus (RSV) is one of the most common viruses infecting the respiratory tracts of infants. The rapid and sensitive detection of RSV is important to minimize the incidence of infection. In this study, novel monoclonal antibodies (mAbs; B11A5 and E8A11) against RSV nucleoprotein (NP) were developed and applied to develop a rapid fluorescent immunochromatographic strip test (FICT), employing europium nanoparticles as the fluorescent material. For the FICT, the limits of detection of the antigen and virus were 1.25 µg/mL and 4.23 × 10(6) TCID(50)/mL, respectively, corresponding to 4.75 × 10(6) ± 5.8 ×10(5) (mean ± SD) RNA copy numbers per reaction mixture for RSV NP. A clinical study revealed a sensitivity of 90% (18/20) and specificity of 98.18% (108/110) for RSV detection when comparing the performance to that of reverse transcription polymerase chain reaction (RT-PCR), representing a 15% improvement in sensitivity over the SD Bioline rapid kit. This newly developed FICT could be a useful tool for the rapid diagnosis of RSV infection.
has issue date	2018-10-02(xsd:dateTime)
bibo:doi	10.3390/ijms19103013
bibo:pmid	30279406
has license	cc-by
sha1sum (hex)	0599be2719a0557e53ffb238765c811578a0cc9f
schema:url	https://doi.org/10.3390/ijms19103013
resource representing a document's title	Development of a Rapid Fluorescent Immunochromatographic Test to Detect Respiratory Syncytial Virus
has PubMed Central identifier	PMC6212954
has PubMed identifier	30279406
schema:publication	Int J Mol Sci
resource representing a document's body	covid:0599be2719a0557e53ffb238765c811578a0cc9f#body_text
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