About: Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation
Creator	Chen, Hui-Wen Chattopadhyay, Saborni Chen, Jui-Yi Hu, Che-Ming
Source	Medline; PMC
abstract	Synthetic nanoparticles play an increasingly significant role in vaccine design and development as many nanoparticle vaccines show improved safety and efficacy over conventional formulations. These nanoformulations are structurally similar to viruses, which are nanoscale pathogenic organisms that have served as a key selective pressure driving the evolution of our immune system. As a result, mechanisms behind the benefits of nanoparticle vaccines can often find analogue to the interaction dynamics between the immune system and viruses. This review covers the advances in vaccine nanotechnology with a perspective on the advantages of virus mimicry towards immune potentiation. It provides an overview to the different types of nanomaterials utilized for nanoparticle vaccine development, including functionalization strategies that bestow nanoparticles with virus-like features. As understanding of human immunity and vaccine mechanisms continue to evolve, recognizing the fundamental semblance between synthetic nanoparticles and viruses may offer an explanation for the superiority of nanoparticle vaccines over conventional vaccines and may spur new design rationales for future vaccine research. These nanoformulations are poised to provide solutions towards pressing and emerging human diseases.
has issue date	2017-06-09(xsd:dateTime)
bibo:doi	10.7150/ntno.19796
bibo:pmid	29071191
has license	cc-by-nc
sha1sum (hex)	05a12a1fb4a86a4158ad027b911092cfc25bc40b
schema:url	https://doi.org/10.7150/ntno.19796
resource representing a document's title	Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation
has PubMed Central identifier	PMC5646730
has PubMed identifier	29071191
schema:publication	Nanotheranostics
resource representing a document's body	covid:05a12a1fb4a86a4158ad027b911092cfc25bc40b#body_text
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