About: A living systematic review protocol for COVID-19 clinical trial registrations

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A living systematic review protocol for COVID-19 clinical trial registrations
Creator	Guérin, Philippe Maguire, Brittany Bj, Maguire Cutts Australia, Julia
source	Medline; PMC; WHO
abstract	Since the coronavirus disease 2019 (COVID-19) outbreak was identified in December 2019 in Wuhan, China, a strong response from the research community has been observed with the proliferation of independent clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies. While there is no intervention for the prevention or treatment of COVID-19 with proven clinical efficacy to date, tools to distil the current research landscape by intervention, level of evidence and those studies likely powered to address future research questions is essential. This living systematic review aims to provide an open, accessible and frequently updated resource summarising the characteristics of COVID-19 clinical trial registrations. Weekly search updates of the WHO International Clinical Trials Registry Platform (ICTRP) and source registries will be conducted. Data extraction by two independent reviewers of trial characteristic variables including categorisation of trial design, geographic location, intervention type and targets, level of evidence and intervention adaptability to low resource settings will be completed. Descriptive and thematic synthesis will be conducted. A searchable and interactive visualisation of the results database will be created, and made openly available online. Weekly results from the continued search updates will be published and made available on the Infectious Diseases Data Observatory (IDDO) website ( COVID-19 website). This living systematic review will provide a useful resource of COVID-19 clinical trial registrations for researchers in a rapidly evolving context. In the future, this sustained review will allow prioritisation of research targets for individual patient data meta-analysis.
has issue date	2020-04-02(xsd:dateTime)
bibo:doi	10.12688/wellcomeopenres.15821.1
bibo:pmid	32292826
has license	cc-by
sha1sum (hex)	05ac1ec253ec738ab9f78ca477e85a51f7186ced
schema:url	https://doi.org/10.12688/wellcomeopenres.15821.1
resource representing a document's title	A living systematic review protocol for COVID-19 clinical trial registrations
has PubMed Central identifier	PMC7141164
has PubMed identifier	32292826
schema:publication	Wellcome Open Res
resource representing a document's body	covid:05ac1ec253ec738ab9f78ca477e85a51f7186ced#body_text
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