About: Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity

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About: Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity
Creator	Zarubaev, Vladimir Yarovaya, Olga Chernyshov, Vladimir Esaulkova, Yana Fadeev, Dmitry Muryleva, Anna Sinegubova, Katherina Gatilov, V Nariman, · Salakhutdinov, F Yuriy, ·
source	PMC
abstract	ABSTRACT: An effective technique for one-stage synthesis of new polycyclic nitrogen-containing compounds has been developed. The procedure involves refluxing mixtures of camphoric acid with aliphatic or aromatic diamine without catalysts. In cases where the starting amine has a low boiling point (less than 200 °C), phenol is used as a solvent, as it is the most optimal one for obtaining products with good yields. It has been shown that the use of Lewis acids as catalysts reduces the yield of the reaction products. A set of compounds have been synthesized, which can be attributed to synthetic analogues of alkaloids. In vitro screening for activity influenza virus A was carried out for the obtained compounds. The synthesized quinazoline-like agent 14 has inhibitory activity against different strains of influenza viruses. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11030-019-09932-9) contains supplementary material, which is available to authorized users.
has issue date	2019-02-28(xsd:dateTime)
bibo:doi	10.1007/s11030-019-09932-9
bibo:pmid	30820742
has license	no-cc
sha1sum (hex)	05b31d35ee224d7be91c154c8af12f987948188b
schema:url	https://doi.org/10.1007/s11030-019-09932-9
resource representing a document's title	Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity
has PubMed Central identifier	PMC7223885
has PubMed identifier	30820742
schema:publication	Mol Divers
resource representing a document's body	covid:05b31d35ee224d7be91c154c8af12f987948188b#body_text
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