About: Transcriptomic analysis of COVID-19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection

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About: Transcriptomic analysis of COVID-19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptomic analysis of COVID-19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection
Creator	Shoenfeld, Yehuda Fagone, Paolo Basile, Maria Bramanti, Alessia Bramanti, Placido Cavalli, Eugenio Nicoletti, Ferdinando Petralia, Maria Spandidos, A
Source	PMC
abstract	The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-CoV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for COVID-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-CoV-2 infection may further improve our understanding of COVID-19 pathogenesis and suggest better therapeutic strategies.
has issue date	2020-08-12(xsd:dateTime)
bibo:doi	10.3892/ijmm.2020.4702
has license	cc-by-nc-nd
sha1sum (hex)	061c0ecf9241defb49f55ce85e541de627478a0c
schema:url	https://doi.org/10.3892/ijmm.2020.4702
resource representing a document's title	Transcriptomic analysis of COVID-19 lungs and bronchoalveolar lavage fluid samples reveals predominant B cell activation responses to infection
has PubMed Central identifier	PMC7447313
schema:publication	Int J Mol Med
resource representing a document's body	covid:061c0ecf9241defb49f55ce85e541de627478a0c#body_text
is schema:about of	named entity 'SARS-coV-2 virus' named entity 'infection' named entity 'data' named entity 'B cell' named entity 'predominant' named entity 'samples' named entity 'responses' named entity 'IMMUNE RESPONSES' named entity 'caused' named entity 'coronavirus' named entity 'therapeutic' named entity 'therapeutic' named entity 'revealed' named entity 'therapeutic strategies' named entity 'SARS-coV-2' named entity 'infection' named entity 'hyperinflammation' named entity 'cOVId-19' named entity 'bronchoalveolar lavage fluid' named entity 'immune responses' named entity 'cXcL10' named entity 'corticosteroids' named entity 'Editor-in-chief' named entity 'cOVId-19' named entity 'dendritic cells' named entity 'lungs' named entity 'virus' named entity 'signaling pathway' named entity 'cOVId-19' named entity 'acute respiratory distress syndrome' named entity 'transmission rate' named entity 'RNA-seq' named entity 'rapamycin' named entity 'BALF' named entity 'COVID' named entity 'organ failure' named entity 'MOI' named entity 'Illumina' named entity 'PI3K' named entity 'cOVId-19' named entity 'mTOR inhibitors' named entity 'antibodies' named entity 'cOVId-19' named entity 'Messina' named entity 'NcBI' named entity 'SARS-coV-2' named entity 'lung' named entity 'NFKB1' named entity 'whole-genome' named entity 'plasma cells' named entity 'infection' named entity 'SARS-coV-2' named entity 'SARS-coV-2' named entity 'plasmacytoid' named entity 'autoimmune diseases' named entity 'transcription factors' named entity 'autopsy' named entity 'consciousness' named entity 'SARS-coV-2' named entity 'TNF' named entity 'SARS-coV-2' named entity 'leukocyte' named entity 'hyperinflammation' named entity 'SARS-coV-2' named entity 'therapeutic strategies' named entity 'Immune cell' named entity 'SARS-coV-2' named entity 'basophils' named entity 'cd8' named entity 'Lung' named entity 'gene signature' named entity 'SARS-coV-2' named entity 'deconvolution' named entity 'SARS-coV-2' named entity 'human lung'

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