About: The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-CoV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for COVID-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-CoV-2 infection may further improve our understanding of COVID-19 pathogenesis and suggest better therapeutic strategies.   Goto Sponge  NotDistinct  Permalink

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  • The outbreak of the 2019 coronavirus disease (named, COVID-19), caused by the novel SARS-CoV-2 virus, represents a worldwide severe threat to public health. It is of the utmost importance to characterize the immune responses against the SARS-CoV-2 and the mechanisms of hyperinflammation, in order to design better therapeutic strategies for COVID-19. In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-CoV-2 infection may further improve our understanding of COVID-19 pathogenesis and suggest better therapeutic strategies.
Subject
  • Virology
  • Therapy
  • Zoonoses
  • Immune system
  • Viral respiratory tract infections
  • COVID-19
  • Occupational safety and health
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