About: G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications
Creator	Chan, Chun-Yin Ji, Danyang Kwok, Chun Umar, Mubarak
Source	PMC
abstract	Guanine (G)-quadruplexes (G4s) are unique nucleic acid structures that are formed by stacked G-tetrads in G-rich DNA or RNA sequences. G4s have been reported to play significant roles in various cellular events in both macro- and micro-organisms. The identification and characterization of G4s can help to understand their different biological roles and potential applications in diagnosis and therapy. In addition to biophysical and biochemical methods to interrogate G4 formation, G4 fluorescent turn-on ligands can be used to target and visualize G4 formation both in vitro and in cells. Here, we review several representative classes of G4 fluorescent turn-on ligands in terms of their interaction mechanism and application perspectives. Interestingly, G4 structures are commonly identified in DNA and RNA aptamers against targets that include proteins and small molecules, which can be utilized as G4 tools for diverse applications. We therefore also summarize the recent development of G4-containing aptamers and highlight their applications in biosensing, bioimaging, and therapy. Moreover, we discuss the current challenges and future perspectives of G4 fluorescent turn-on ligands and G4-containing aptamers.
has issue date	2019-06-30(xsd:dateTime)
bibo:doi	10.3390/molecules24132416
bibo:pmid	31262059
has license	cc-by
sha1sum (hex)	061eb24a1462aba7b53e6c099fe5d4bd046dd56a
schema:url	https://doi.org/10.3390/molecules24132416
resource representing a document's title	G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications
has PubMed Central identifier	PMC6650947
has PubMed identifier	31262059
schema:publication	Molecules
resource representing a document's body	covid:061eb24a1462aba7b53e6c099fe5d4bd046dd56a#body_text
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