About: The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B
Creator	Cho, Hye-Sun Jeon, Jae-Heung Kim, Hyun-Soon Moon, Ki-Beom Park, Hee Joung, Young
Source	PMC
abstract	Disease prevention through vaccination is considered to be the greatest contribution to public health over the past century. Every year more than 100 million children are vaccinated with the standard World Health Organization (WHO)-recommended vaccines including hepatitis B (HepB). HepB is the most serious type of liver infection caused by the hepatitis B virus (HBV), however, it can be prevented by currently available recombinant vaccine, which has an excellent record of safety and effectiveness. To date, recombinant vaccines are produced in many systems of bacteria, yeast, insect, and mammalian and plant cells. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. Research groups worldwide have attempted to develop more efficacious plant-derived vaccines for over 30 diseases, most frequently HepB and influenza. More inspiring, approximately 12 plant-made antigens have already been tested in clinical trials, with successful outcomes. In this study, the latest information from the last 10 years on plant-derived antigens, especially hepatitis B surface antigen, approaches are reviewed and breakthroughs regarding the weak points are also discussed.
has issue date	2016-10-13(xsd:dateTime)
bibo:doi	10.3390/ijms17101715
bibo:pmid	27754367
has license	cc-by
sha1sum (hex)	0660d9281c1607ca1ca9cb62dfa00b56f49ddee1
schema:url	https://doi.org/10.3390/ijms17101715
resource representing a document's title	The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B
has PubMed Central identifier	PMC5085746
has PubMed identifier	27754367
schema:publication	Int J Mol Sci
resource representing a document's body	covid:0660d9281c1607ca1ca9cb62dfa00b56f49ddee1#body_text
is schema:about of	named entity 'RECOMBINANT VACCINES' named entity 'INFORMATION' named entity 'EVERY YEAR' named entity 'PLANT-' named entity 'CENTURY' named entity 'RECOMMENDED' named entity 'AVAILABLE' named entity 'GROUPS' named entity 'RECOMBINANT VACCINES' named entity 'GREATEST' named entity 'DERIVED' named entity 'PAST' named entity 'YEARS' named entity 'SAFETY' named entity 'MORE THAN' named entity 'HEPATITIS B VIRUS' named entity 'APPROXIMATELY' named entity 'REVIEWED' named entity 'FREQUENTLY' named entity 'CLINICAL TRIALS' named entity 'APPROPRIATE' named entity 'TARGET' named entity 'CONSIDERABLE' named entity 'CONSIDERED' named entity 'MODIFICATION' named entity 'INSECT' named entity 'TYPE' named entity 'VACCINATION' named entity 'WORLDWIDE' named entity 'HEPATITIS B SURFACE ANTIGEN' named entity 'MAMMALIAN' named entity 'RESEARCH' named entity 'HAVE' named entity 'PUBLIC HEALTH' named entity 'CURRENTLY' named entity 'TESTED' named entity 'SYSTEMS' named entity 'INTRINSIC' named entity 'ANTIGENS' named entity 'VACCINES' named entity 'HEPATITIS B' named entity 'YEARS' named entity 'HEPATITIS B' named entity 'DISEASES' named entity '100' named entity 'LATEST' named entity 'INCLUDING' named entity 'TERMS' named entity 'WORLD HEALTH ORGANIZATION' named entity 'BACTERIA' named entity 'RECORD OF' named entity 'RECEIVED' named entity 'POINTS' named entity 'DERIVED' named entity 'PLANT-' named entity 'SCIENCES' named entity 'MOLECULAR' named entity 'ATTEMPTED' named entity 'THESE' named entity 'OUTCOMES' named entity 'CAUSED BY' named entity 'INFLUENZA' named entity 'ATTENTION' named entity 'PLANT CELLS' named entity 'DATE' named entity 'SUCCESSFUL' named entity 'CHILDREN' named entity 'CONTRIBUTION' named entity 'EFFECTIVENESS' named entity 'VACCINATED' named entity 'STANDARD' named entity 'LIVER INFECTION' named entity 'MILLION' named entity 'BREAKTHROUGHS' named entity 'APPROACHES' named entity 'DISEASE PREVENTION'

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