About: Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites

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About: Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites
Creator	Adja, Akré Aka, Kakou Assi, Serge Dipomin, F N'cho Tchiekoi, Bertin Poinsignon, Anne Remoue, Franck Sagna, André Traoré, Zoh, Dounin
source	PMC
abstract	BACKGROUND: In malaria-endemic areas, human populations are frequently exposed to immunomodulatory salivary components injected during mosquito blood feeding. The consequences on pathogen-specific immune responses are not well known. This study evaluated and compared the humoral responses specific to merozoite stage vaccine candidates of Plasmodium falciparum, in children differentially exposed to Anopheles bites in a natural setting. METHODS: The cross-sectional study was carried out in Bouaké (Côte d’Ivoire) where entomological data and blood samples from children (0–14 years) were collected in two sites with similar malaria prevalence. Antibody (IgG, IgG1, IgG3) responses to PfAMA1 and PfMSP1 were evaluated by ELISA. Univariate and multivariate analysis were performed to assess the relationship between the immune responses to P. falciparum antigens and exposure to Anopheles bites in the total cohort and in each site, separately. The individual level of exposure to Anopheles bites was evaluated by quantifying specific IgG response to the Anopheles gSG6-P1 salivary peptide, which represents a proxy of Anopheles exposure. RESULTS: The anti-Plasmodium humoral responses were different according to the level of exposure of children, with those highly exposed to Anopheles presenting significantly lower antibody responses to PfMSP1 in total population (IgG and IgG3) and in Petessou village (IgG, IgG1, IgG3). No significant difference was seen for PfAMA1 antigen between children differently exposed to Anopheles. In Dar-es-Salam, a neighbourhood where a high Culex density was reported, children presented very low antibody levels specific to both antigens, and no difference according to the exposure to Anopheles bites was found. CONCLUSION: These findings may suggest that immunomodulatory components of Anopheles saliva, in addition to other factors, may participate to the modulation of the humoral response specific to Plasmodium merozoite stage antigens. This epidemiological observation may form a starting point for additional work to decipher the role of mosquito saliva on the modulation of the anti-Plasmodium acquired immunity and clinical protection in combining both field and ex vivo immunological studies.
has issue date	2020-02-21(xsd:dateTime)
bibo:doi	10.1186/s12936-020-03160-5
bibo:pmid	32085710
has license	cc-by
sha1sum (hex)	067811215e2e69471101d2e2995f14754f1383eb
schema:url	https://doi.org/10.1186/s12936-020-03160-5
resource representing a document's title	Pattern of antibody responses to Plasmodium falciparum antigens in individuals differentially exposed to Anopheles bites
has PubMed Central identifier	PMC7033907
has PubMed identifier	32085710
schema:publication	Malar J
resource representing a document's body	covid:067811215e2e69471101d2e2995f14754f1383eb#body_text
is schema:about of	named entity 'vaccine' named entity 'bites' named entity 'antigens' named entity 'Pattern' named entity 'VACCINE' named entity 'EVALUATED' named entity 'ANOPHELES' named entity 'merozoite' named entity 'vaccine' named entity 'Anopheles' named entity 'Plasmodium falciparum' named entity 'immune responses' named entity 'Anopheles' named entity 'immune response' named entity 'complex traits' named entity 'goat' named entity 'complex traits' named entity 'IgG1' named entity 'IgG1' named entity 'merozoite' named entity 'IgG3' named entity 'epidemiological' named entity 'double blind' named entity 'saliva' named entity 'malaria' named entity 'Anopheles' named entity 'Plasmodium' named entity 'IgG3' named entity 'acquired immunity' named entity 'malaria' named entity 'Th1' named entity 'peptide' named entity 'murine' named entity 'informed consent' named entity 'rainy season' named entity 'Dar-es-Salam' named entity 'skimmed milk' named entity 'St Louis' named entity 'pneumococcal' named entity 'antibody' named entity 'Anopheles' named entity 'Anopheles' named entity 'Anopheles mosquitoes' named entity 'pathogens' named entity 'sulfonic acid' named entity 'immune responses' named entity 'Anopheles' named entity 'vaccine efficacy' named entity 'IgG' named entity 'malaria' named entity 'bone marrow' named entity 'mosquito saliva' named entity 'vaccine' named entity '3.3.3' named entity 'arthropod' named entity 'Culex' named entity 'citrate' named entity 'Plasmodium' named entity 'Vienna' named entity 'biomolecules' named entity 'antigens' named entity 'France' named entity 'Giemsa' named entity 'antigens' named entity 'IgG' named entity 'quality control' named entity 'WHO' named entity 'tick' named entity 'Denmark' named entity 'heterogeneity' named entity 'apical membrane antigen' named entity 'Parasitological'

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