About: Higher frequency of hepatic steatosis at CT among COVID-19-positive patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Higher frequency of hepatic steatosis at CT among COVID-19-positive patients
Creator	Cruz, Ribeiro Bruna, · Callegari Barbisan, Cinthia Italo, · Libânio, Brandão Medeiros De Araújo, · Medeiros, Augusto Seidel, Kamila Torres, Ulysses
Source	Medline; PMC
abstract	PURPOSE: Recent studies have demonstrated that obesity is significantly associated with increased disease severity, hospitalizations and mortality in COVID-19, with a potential role in the pathogenesis and prevalence in the new pandemic. The association with hepatic steatosis, however, a condition closely related to obesity within the spectrum of systemic metabolic dysfunctions, remains to be elucidated. We aimed to evaluate the frequency of hepatic steatosis as incidentally detected in chest CT examinations of COVID-19 positive patients in comparison to non-infected controls. METHODS: A retrospective study was performed with 316 patients (204 RT-PCR positive; 112 RT-PCR negative and chest CT negative). Steatosis was measured with placement of a single ROI in the right lobe of the liver (segments VI-VII) and defined as a liver attenuation value ≤ 40 HU. RESULTS: The frequency of hepatic steatosis was higher in the RT-PCR positive group in comparison to controls (31.9% vs. 7.1%, p < 0.001). Logistic linear regression analysis showed a 4.7 times odds of steatosis in the COVID-19 positive group as compared to controls after adjusting for age and sex (OR 4.698; 95% IC 2.12–10.41, p < 0.001). CONCLUSION: A significantly higher prevalence of steatosis was found among COVID-19 positive individuals. These findings are in accordance with other recent studies linking obesity and COVID-19 infection, as there is an intricate relationship between liver steatosis, metabolic syndrome and obesity. Further studies are required to confirm if such association remains after accounting for multiple variables, as well as possible relationships with disease severity and worst clinical outcomes.
has issue date	2020-07-18(xsd:dateTime)
bibo:doi	10.1007/s00261-020-02648-7
bibo:pmid	32683613
has license	no-cc
sha1sum (hex)	068588fd3424ce88a755ae00661fe3d8396dbb68
schema:url	https://doi.org/10.1007/s00261-020-02648-7
resource representing a document's title	Higher frequency of hepatic steatosis at CT among COVID-19-positive patients
has PubMed Central identifier	PMC7368629
has PubMed identifier	32683613
schema:publication	Abdom Radiol (NY)
resource representing a document's body	covid:068588fd3424ce88a755ae00661fe3d8396dbb68#body_text
is schema:about of	named entity 'individuals' named entity 'RT-PCR' named entity 'remains' named entity 'Logistic' named entity 'incidentally' named entity 'COVID-19' named entity 'Results' named entity 'times' named entity 'LINEAR REGRESSION ANALYSIS' named entity 'PREVALENCE' covid:arg/068588fd3424ce88a755ae00661fe3d8396dbb68 named entity 'hepatic steatosis' named entity 'studies' named entity 'positive' named entity 'pathogenesis' named entity 'organ' named entity 'not-for-profit' named entity 'organ' named entity 'CT examinations' named entity 'spleen' named entity 'adipose tissue' named entity 'acute care' named entity 'spleen' named entity 'COVID' named entity 'vaccination' named entity 'Student's t test' named entity 'obesity-hypoventilation syndrome' named entity 'metabolic syndrome' named entity 'steatosis' named entity 'obese persons' named entity 'Siemens Healthcare' named entity 'emergency setting' named entity 'antiviral' named entity 'hepatic steatosis' named entity 'liver' named entity 'hepatic' named entity 'ACE2' named entity 'liver' named entity 'liver' named entity 'vomiting' named entity 'COVID' named entity 'visceral obesity' named entity 'steatosis' named entity 'ACE2' named entity 'sample size' named entity 'RT-PCR' named entity 'T-cell' named entity 'obesity' named entity 'flu syndrome' named entity 'body mass index' named entity 'SARS-CoV-2' named entity 'body mass index' named entity 'COVID-19 infection' named entity 'false-negative' named entity 'COVID-19' named entity 'fatty liver disease' named entity 'COVID' named entity 'obese' named entity 'BMI' named entity 'control-group' named entity 'COVID' named entity 'REDCap' named entity 'infection' named entity 'PCR' named entity 'univariate analysis' named entity 'COVID' named entity 'liver' named entity 'statistically significant' named entity 'liver biopsy' named entity 'steatosis' named entity 'metabolic syndrome' named entity 'COVID-19' named entity 'collimation'

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