About: Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

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About: Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic
Creator	Sinkora, Marek Butler, J Faaberg, Kay Golde, William Loving, Crystal Zhang, • Lager, •
Source	Medline; PMC
abstract	Porcine reproductive and respiratory disease syndrome (PRRS) is a viral pandemic that especially affects neonates within the “critical window” of immunological development. PRRS was recognized in 1987 and within a few years became pandemic causing an estimated yearly $600,000 economic loss in the USA with comparative losses in most other countries. The causative agent is a single-stranded, positive-sense enveloped arterivirus (PRRSV) that infects macrophages and plasmacytoid dendritic cells. Despite the discovery of PRRSV in 1991 and the publication of >2,000 articles, the control of PRRS is problematic. Despite the large volume of literature on this disease, the cellular and molecular mechanisms describing how PRRSV dysregulates the host immune system are poorly understood. We know that PRRSV suppresses innate immunity and causes abnormal B cell proliferation and repertoire development, often lymphopenia and thymic atrophy. The PRRSV genome is highly diverse, rapidly evolving but amenable to the generation of many mutants and chimeric viruses for experimental studies. PRRSV only replicates in swine which adds to the experimental difficulty since no inbred well-defined animal models are available. In this article, we summarize current knowledge and apply it toward developing a series of provocative and testable hypotheses to explain how PRRSV immunomodulates the porcine immune system with the goal of adding new perspectives on this disease.
has issue date	2014-07-01(xsd:dateTime)
bibo:doi	10.1007/s12026-014-8549-5
bibo:pmid	24981123
has license	no-cc
sha1sum (hex)	072b4294e6041bdd4845480b8549470ca6847f39
schema:url	https://doi.org/10.1007/s12026-014-8549-5
resource representing a document's title	Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic
has PubMed Central identifier	PMC7091131
has PubMed identifier	24981123
schema:publication	Immunol Res
resource representing a document's body	covid:072b4294e6041bdd4845480b8549470ca6847f39#body_text
is schema:about of	named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME' named entity 'CONTROL' named entity 'ARTERIVIRUS' named entity 'LARGE VOLUME' named entity 'ARTICLE' named entity 'SYNDROME' named entity 'IS A' named entity 'PROBLEMATIC' named entity 'ADDING' named entity 'IMMUNOLOGICAL' named entity 'SWINE' named entity 'LYMPHOPENIA' named entity 'CURRENT' named entity 'PLASMACYTOID' named entity 'HOW' named entity 'VIRAL' named entity 'DIFFICULTY' named entity 'VIRUSES' named entity 'CAUSES' named entity 'IMMUNE SYSTEM' named entity 'HIGHLY' named entity 'NEW' named entity 'REPRODUCTIVE' named entity 'POSITIVE' named entity 'PRRSV' named entity 'KNOWLEDGE' named entity 'BUT' named entity 'UNDERSTOOD' named entity 'WINDOW' named entity 'GENERATION' named entity 'CAUSING' named entity 'DESCRIBING' named entity 'EXPERIMENTAL STUDIES' named entity 'DEVELOPING' named entity 'RESPIRATORY DISEASE' named entity 'USA' named entity 'ARTICLES' named entity 'DISCOVERY' named entity 'DISEASE' named entity 'DENDRITIC CELLS' named entity 'RAPIDLY' named entity '1987' named entity 'YEARS' named entity 'EVOLVING' named entity 'DIVERSE' named entity 'GENOME' named entity 'MOLECULAR' named entity 'COUNTRIES' named entity 'ANIMAL MODELS ' named entity 'TO EXPLAIN' named entity 'INFECTS' named entity 'DEVELOPMENT' named entity 'WELL-DEFINED' named entity 'MECHANISMS' named entity 'MUTANTS' named entity 'CELLULAR' named entity 'REPERTOIRE' named entity 'POORLY' named entity 'AVAILABLE' named entity 'MACROPHAGES' named entity 'IMMUNE' named entity 'PANDEMIC' named entity 'SINGLE' named entity 'ABNORMAL B CELL PROLIFERATION' named entity 'NEONATES' named entity 'LITERATURE' named entity 'HOST' named entity 'CAUSATIVE AGENT' named entity 'SERIES' named entity 'CHIMERIC' named entity 'APPLY' named entity 'ECONOMIC LOSS' named entity 'INNATE IMMUNITY' named entity 'SUPPRESSES' named entity 'INBRED'

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