About: Short- and long-term exposure to methamidophos impairs spermatogenesis in mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Short- and long-term exposure to methamidophos impairs spermatogenesis in mice
Creator	Andersen, Monica Carvalho, Renata Júnior, Walter Mazaro-Costa, Renata Mota, Gabriela Rodrigues, Thamyres
source	Elsevier; Medline; PMC
abstract	Methamidophos (MET) is a pesticide that has toxic properties, including effects on fertility. This study aimed to assess the joint action of treatment time and exposure to methamidophos on the male reproductive system. MET was orally administered to adult male Swiss mice at a dose of 0.004 mg.kg(−1) for 15 and 50 consecutive days. The following parameters were evaluated: weight of reproductive organs, spermatogenesis, sperm and Sertoli cell count, daily sperm production and sperm transit time. Short-term exposure to methamidophos induced a decrease in epididymal weight. The frequency of stages V–VI of spermatogenesis increased and the frequency of stage IX decreased. In the epididymis, sperm transit time (caput/corpus) was reduced and the relative sperm number (cauda) increased. Long-term exposure induced an increase in the frequencies of stages I–IV and V-VI and decreased the stages VII-VIII and IX. The number of Sertoli cells with evident nucleoli was reduced in both exposures. These results confirm the reproductive toxicity of MET.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1016/j.repbio.2020.05.003
bibo:pmid	32405287
has license	no-cc
sha1sum (hex)	0746a784bafaec90b799280992192554c78431a4
schema:url	https://doi.org/10.1016/j.repbio.2020.05.003
resource representing a document's title	Short- and long-term exposure to methamidophos impairs spermatogenesis in mice
has PubMed Central identifier	PMC7218378
has PubMed identifier	32405287
schema:publication	Reprod Biol
resource representing a document's body	covid:0746a784bafaec90b799280992192554c78431a4#body_text
is schema:about of	named entity 'male' named entity 'male reproductive system' named entity 'Long-term' named entity 'Swiss' named entity 'REDUCED' named entity 'ASSESS' named entity 'METHAMIDOPHOS' named entity 'caput' named entity 'frequency' named entity 'MET' named entity 'methamidophos' named entity 'pesticide' named entity 'toxic properties' named entity 'sperm' named entity 'epididymal' named entity 'sperm production' named entity 'spermatogenesis' named entity 'fertility' named entity 'long-term' named entity 'methamidophos' named entity 'long-term' named entity 'mAChR' named entity 'acetylcholine' named entity 'short-term' named entity 'sperm production' named entity 'downregulation' named entity 'Organophosphates' named entity 'apoptosis' named entity 'Cyp11a1' named entity 'transit time' named entity 'spermatocytes' named entity 'rodents' named entity 'testes' named entity 'spermatogenesis' named entity 'Covid 19' named entity 'spermatids' named entity 'long-term' named entity 'sperm quality' named entity 'nuclei' named entity 'epididymal' named entity 'sperm' named entity 'epithelial cell' named entity 'statistically significant' named entity 'phosphorylate' named entity 'epididymal' named entity 'redox processes' named entity 'statistically significant' named entity 'mitotic' named entity 'spermatids' named entity 'male infertility' named entity 'male fertility' named entity 'toxic effects' named entity 'cholinergic' named entity 'spermatozoa' named entity 'protein phosphorylation' named entity 'motility' named entity 'spermatogenesis' named entity 'ACh' named entity 'spermatogenic' named entity 'Sertoli cells' named entity 'germinal epithelium' named entity 'spermatozoa' named entity 'synapses' named entity 'control group' named entity 'sperm' named entity 'spermatogenic' named entity 'reproductive organs' named entity 'sperm count' named entity 'spermatogenic' named entity 'chromatin' named entity 'acceptable daily intake' named entity 'human life' named entity 'Spermiation' named entity 'transit time' named entity 'long-term' named entity 'short-term'

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