About: CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse

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About: CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse
Creator	Zhao, Ran Kaur, Anupinder Liang, Brannen Schacke, Wolfgang Vernier, Kaitlyn Winnicka, Beata Shapiro, Linda Pereira, Flavia Aguila, Hector Fenteany, Fiona Grant, Christina Montrose, David O'conor, Catherine Rosenberg, Daniel
Source	Medline; PMC
abstract	The robust and consistent expression of the CD13 cell surface marker on very early as well as differentiated myeloid hematopoietic cells has prompted numerous investigations seeking to define roles for CD13 in myeloid cells. To address the function of myeloid CD13 directly, we created a CD13 null mouse and assessed the responses of purified primary macrophages or DCs from WT and CD13 null animals in cell assays and inflammatory disease models, where CD13 has been implicated previously. We find that mice lacking CD13 develop normally with normal hematopoietic profiles except for an increase in thymic but not peripheral T cell numbers. Moreover, in in vitro assays, CD13 appears to be largely dispensable for the aspects of phagocytosis, proliferation, and antigen presentation that we tested, although we observed a slight decrease in actin-independent erythrocyte uptake. However, in agreement with our published studies, we show that lack of monocytic CD13 completely ablates anti-CD13-dependent monocyte adhesion to WT endothelial cells. In vivo assessment of four inflammatory disease models showed that lack of CD13 has little effect on disease onset or progression. Nominal alterations in gene expression levels between CD13 WT and null macrophages argue against compensatory mechanisms. Therefore, although CD13 is highly expressed on myeloid cells and is a reliable marker of the myeloid lineage of normal and leukemic cells, it is not a critical regulator of hematopoietic development, hemostasis, or myeloid cell function.
has issue date	2010-04-29(xsd:dateTime)
bibo:doi	10.1189/jlb.0210065
bibo:pmid	20430777
has license	green-oa
sha1sum (hex)	07716847595c01ee5241f69b4da56b04a44b41e3
schema:url	https://doi.org/10.1189/jlb.0210065
resource representing a document's title	CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse
has PubMed Central identifier	PMC2908940
has PubMed identifier	20430777
schema:publication	Journal of Leukocyte Biology
resource representing a document's body	covid:07716847595c01ee5241f69b4da56b04a44b41e3#body_text
is schema:about of	named entity 'T cell' named entity 'reliable' named entity 'purified' named entity 'models' named entity 'APRIL 6' covid:arg/07716847595c01ee5241f69b4da56b04a44b41e3 named entity 'CD13' named entity 'myeloid' named entity 'observed' named entity 'Therefore' named entity 'highly' named entity 'mechanisms' named entity 'inflammatory disease' named entity 'expression' named entity 'animals' named entity 'hematopoietic' named entity 'Nominal' named entity 'mice' named entity 'null' named entity 'surface' named entity 'early' named entity 'myeloid lineage' named entity 'monocytic' named entity 'CD13' named entity 'thymic' named entity 'phagocytosis' named entity 'CD13' named entity 'null' named entity 'cell surface' named entity 'ulcerated' named entity 'cleavage' named entity 'reverse-transcribed' named entity 'gene promoter' named entity 'peptides' named entity 'ligand' named entity 'Framingham' named entity 'ELISA assay' named entity 'mice' named entity 'dye' named entity 'arthritis' named entity 'TRIzol' named entity 'thioglycollate broth' named entity 'mRNA' named entity 'myeloid cells' named entity 'binding site' named entity 'transgenic mice' named entity 'splicing' named entity 'myeloid cell' named entity 'enzyme activity' named entity 'mast cells' named entity 'Fluorescence' named entity 'complement' named entity 'murine' named entity 'acetone' named entity 'CD13' named entity 'HCl' named entity 'myeloid lineage' named entity 'brush border' named entity 'endothelial' named entity 'peritonitis' named entity 'angiogenesis' named entity 'CD13' named entity 'microfilament' named entity 'monocytes' named entity 'mAb' named entity 'cytochalasin' named entity 'adhesion molecules' named entity 'fluorescence'

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