About: Porcine alveolar macrophage polarization is involved in inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication

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About: Porcine alveolar macrophage polarization is involved in inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine alveolar macrophage polarization is involved in inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication
Creator	Cai, Xuehui Liu, Qiang Xu, Lu He, Xijun Hu, Shouping Li, Yiru Wang, Longtao Zhang, Zhuo
Source	Medline; PMC
abstract	Macrophage polarization is a process by which macrophages acquire a distinct phenotypic and functional profile in response to microenvironmental signals. The classically and alternatively activated (M1 and M2, respectively) macrophage phenotypes are defined by the specific molecular characteristics induced in response to prototypic pro- and anti-inflammatory cues. In this study, we used LPS/IFN-γ and IL-4 to stimulate porcine alveolar macrophages (PAMs) in vitro and investigated the expression changes of several novel markers during macrophage polarization. Notably, we found that LPS/IFN-γ-stimulated PAMs express prototypical M1 molecules, whereas IL-4-stimulated PAMs express M2 molecules. We also demonstrated that replication of the highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) strain HuN4 was effectively suppressed in LPS/IFN-γ-stimulated M1 PAMs (M1 type), but not IL-4 stimulated M2 PAMs. However, this was not observed with the classic, less pathogenic CH-1a strain. Moreover, we found that M2 marker expression gradually increased after PAM infection with PRRSV, whereas no significant changes were found with M1 marker expression, suggesting that PRRSV infection may skew macrophage polarization towards an M2 phenotype. Finally, we found that anti-viral cytokine expression was significantly higher in M1 macrophages than in M2 macrophages or nonpolarized controls. In summary, our results show that PRRSV replication was significantly impaired in M1 PAMs, which may serve as a foundation for further understanding of the dynamic phenotypic changes during macrophage polarization and their effects on viral infection.
has issue date	2017-09-17(xsd:dateTime)
bibo:doi	10.1292/jvms.17-0258
bibo:pmid	28924090
has license	cc-by-nc-nd
sha1sum (hex)	08079db5747d09016612f319e154ff81c4d9aef5
schema:url	https://doi.org/10.1292/jvms.17-0258
resource representing a document's title	Porcine alveolar macrophage polarization is involved in inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication
has PubMed Central identifier	PMC5709573
has PubMed identifier	28924090
schema:publication	J Vet Med Sci
resource representing a document's body	covid:08079db5747d09016612f319e154ff81c4d9aef5#body_text
is schema:about of	named entity 'ALVEOLAR MACROPHAGE' named entity 'STIMULATED' named entity 'PAM' named entity 'ACQUIRE' named entity 'IL-4' named entity 'SIGNIFICANT' named entity 'OUR' named entity 'MACROPHAGE POLARIZATION' named entity 'DEFINED' named entity 'CLASSIC' named entity 'MACROPHAGES' named entity 'SERVE' named entity 'STIMULATE' named entity 'PHENOTYPES' named entity 'ALVEOLAR MACROPHAGES' named entity 'MOLECULAR' named entity 'SUMMARY' named entity 'REPLICATION' named entity 'MARKER' named entity 'INVESTIGATED' named entity 'MARKERS' named entity 'LPS' named entity 'NOVEL' named entity 'ANTI-INFLAMMATORY' named entity 'DEMONSTRATED' named entity 'phenotype' named entity 'skew' named entity 'higher' named entity 'stimulate' named entity 'macrophages' named entity 'pathogenic' named entity 'PAMs' named entity 'defined' named entity 'PORCINE' named entity 'PAPER' named entity 'VIRAL INFECTION' named entity 'UNDERSTANDING' named entity 'CHANGES' named entity 'PATHOLOGY' named entity 'STUDY' named entity 'NOT OBSERVED' named entity 'IS A' named entity 'EFFECTS' named entity 'IMPAIRED' named entity 'PHENOTYPE' named entity 'CHARACTERISTICS' named entity 'EXPRESSION' named entity 'HIGHLY' named entity 'FUNCTIONAL' named entity 'STRAIN' named entity 'INVOLVED' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'TYPE' named entity 'PATHOGENIC' named entity 'VIRAL' named entity 'INCREASED' named entity 'SKEW' named entity 'RESULTS' named entity 'MOLECULES' named entity 'SPECIFIC' named entity 'THEIR' named entity 'MACROPHAGE' named entity 'EXPRESS' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'SIGNALS' named entity 'USED' named entity 'FOUND' named entity 'CYTOKINE EXPRESSION' named entity 'ACTIVATED' named entity 'SUPPRESSED' named entity 'PAMS' named entity 'INFECTION' named entity 'IN VITRO' named entity 'INHIBITION'

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