About: Genetic and biological characterisation of Zika virus isolates from different Brazilian regions

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About: Genetic and biological characterisation of Zika virus isolates from different Brazilian regions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genetic and biological characterisation of Zika virus isolates from different Brazilian regions
Creator	Zanluca, Camila Bordignon, Juliano Faoro, Helisson Kuczera, Diogo Duarte, Claudia Koishi, Andrea Cataneo, Depieri Cavalheiro Auwerter, Nathalia Henrique, Allan Luiza, Ana Mosimann, Pamplona Strottmann, Daisy Wowk, Pryscilla
source	PMC
abstract	BACKGROUND: Zika virus (ZIKV) infections reported in recent epidemics have been linked to clinical complications that had never been associated with ZIKV before. Adaptive mutations could have contributed to the successful emergence of ZIKV as a global health threat to a nonimmune population. However, the causal relationships between the ZIKV genetic determinants, the pathogenesis and the rapid spread in Latin America and in the Caribbean remain widely unknown. OBJECTIVES: The aim of this study was to characterise three ZIKV isolates obtained from patient samples during the 2015/2016 Brazilian epidemics. METHODS: The ZIKV genomes of these strains were completely sequenced and in vitro infection kinetics experiments were carried out in cell lines and human primary cells. FINDINGS: Eight nonsynonymous substitutions throughout the viral genome of the three Brazilian isolates were identified. Infection kinetics experiments were carried out with mammalian cell lines A549, Huh7.5, Vero E6 and human monocyte-derived dendritic cells (mdDCs) and insect cells (Aag2, C6/36 and AP61) and suggest that some of these mutations might be associated with distinct viral fitness. The clinical isolates also presented differences in their infectivity rates when compared to the well-established ZIKV strains (MR766 and PE243), especially in their abilities to infect mammalian cells. MAIN CONCLUSIONS: Genomic analysis of three recent ZIKV isolates revealed some nonsynonymous substitutions, which could have an impact on the viral fitness in mammalian and insect cells.
has issue date	2019-08-19(xsd:dateTime)
bibo:doi	10.1590/0074-02760190150
bibo:pmid	31432892
has license	cc-by
sha1sum (hex)	08d0057eaad519e3d6ef88ffbbc2187b2c11f126
schema:url	https://doi.org/10.1590/0074-02760190150
resource representing a document's title	Genetic and biological characterisation of Zika virus isolates from different Brazilian regions
has PubMed Central identifier	PMC6701881
has PubMed identifier	31432892
schema:publication	Mem Inst Oswaldo Cruz
resource representing a document's body	covid:08d0057eaad519e3d6ef88ffbbc2187b2c11f126#body_text
is schema:about of	named entity 'DIFFERENT' named entity 'ZIKA VIRUS' named entity 'POPULATION' named entity 'NEVER' named entity 'UNKNOWN' named entity 'GLOBAL HEALTH' named entity 'CLINICAL' named entity 'PATHOGENESIS' named entity 'GENETIC' named entity 'SUCCESSFUL' named entity 'LATIN AMERICA' named entity 'BACKGROUND' named entity 'REPORTED' named entity 'MUTATIONS' named entity 'EMERGENCE' named entity 'CARIBBEAN' named entity 'ADAPTIVE' named entity 'INFECTIONS' named entity 'ISOLATES' named entity 'EPIDEMICS' named entity 'BRAZILIAN' named entity 'BIOLOGICAL' named entity 'HAVE' named entity 'COMPLICATIONS' named entity 'SPREAD' named entity 'ASSOCIATED WITH' named entity 'RELATIONSHIPS' named entity 'RAPID' named entity 'RECENT' named entity 'THREAT' named entity 'GENETIC' named entity 'REGIONS' named entity 'DETERMINANTS' named entity 'ZIKA VIRUS' covid:arg/08d0057eaad519e3d6ef88ffbbc2187b2c11f126 named entity 'successful' named entity 'mammalian cells' named entity 'nucleotide substitution' named entity 'primers' named entity 'mammalian cell' named entity 'amino acid' named entity 'population' named entity 'Adaptive' named entity 'Zika virus' named entity 'ZIKV' named entity 'Zika' named entity 'pathogenesis' named entity 'ZIKV' named entity 'Caribbean' named entity 'epidemics' named entity 'Brazilian regions' named entity 'Zika' named entity 'host cell' named entity 'Auburn, CA' named entity 'Promega' named entity 'Phylogenetic tree' named entity 'phenotype' named entity 'virus' named entity 'ZIKV' named entity 'ZIKV' named entity 'capsid' named entity 'viruses' named entity 'infection rate' named entity 'Qiagen' named entity 'RT-qPCR' named entity 'GenBank' named entity 'FBS' named entity 'rhesus monkey' named entity 'RNA'

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