About: Phage Display: A Powerful Technology for the Generation of High Specificity Affinity Reagents from Alternative Immune Sources

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phage Display: A Powerful Technology for the Generation of High Specificity Affinity Reagents from Alternative Immune Sources
Creator	Bloom, Laird Cunningham, Orla Finlay, William
Source	Medline; PMC
abstract	Antibodies are critical reagents in many fundamental biochemical methods such as affinity chromatography. As our understanding of the proteome becomes more complex, demand is rising for rapidly generated antibodies of higher specificity than ever before. It is therefore surprising that few investigators have moved beyond the classical methods of antibody production in their search for new reagents. Despite their long-standing efficacy, recombinant antibody generation technologies such as phage display are still largely the tools of biotechnology companies or research groups with a direct interest in protein engineering. In this chapter, we discuss the inherent limitations of classical polyclonal and monoclonal antibody generation and highlight an attractive alternative: generating high specificity, high affinity recombinant antibodies from alternative immune sources such as chickens, via phage display.
has issue date	2010-06-24(xsd:dateTime)
bibo:doi	10.1007/978-1-60761-913-0_6
bibo:pmid	20978962
has license	no-cc
sha1sum (hex)	08e2f1f33e52092cec9bd3df681d1052f8c3dc85
schema:url	https://doi.org/10.1007/978-1-60761-913-0_6
resource representing a document's title	Phage Display: A Powerful Technology for the Generation of High Specificity Affinity Reagents from Alternative Immune Sources
has PubMed Central identifier	PMC7120213
has PubMed identifier	20978962
schema:publication	Protein Chromatography
resource representing a document's body	covid:08e2f1f33e52092cec9bd3df681d1052f8c3dc85#body_text
is schema:about of	named entity 'TECHNOLOGY' named entity 'AFFINITY' named entity 'proteome' named entity 'reagents' named entity 'generation' named entity 'fundamental' named entity 'SPECIFICITY' named entity 'STANDING' named entity 'HIGHER' named entity 'POLYCLONAL' named entity 'PROTEOME' named entity 'REAGENTS' named entity 'AFFINITY CHROMATOGRAPHY' named entity 'SOURCES' named entity 'DEMAND' named entity 'AFFINITY' named entity 'HIGH' named entity 'TOOLS' named entity 'INTEREST' named entity 'ANTIBODY PRODUCTION' named entity 'BIOTECHNOLOGY' named entity 'HAVE' named entity 'MONOCLONAL ANTIBODY' named entity 'SEARCH' named entity 'SOURCES' named entity 'LARGELY' named entity 'GENERATION' named entity 'GROUPS' named entity 'BEYOND' named entity 'HIGH' named entity 'ALTERNATIVE' named entity 'IMMUNE' named entity 'POWERFUL' named entity 'GENERATION' named entity 'COMPLEX' named entity 'NEW' named entity 'LIMITATIONS' named entity 'INVESTIGATORS' named entity 'DISCUSS' named entity 'BIOCHEMICAL' named entity 'GENERATING' named entity 'PHAGE DISPLAY' named entity 'CHICKENS' named entity 'PHAGE DISPLAY' named entity 'REAGENTS' named entity 'METHODS' named entity 'GENERATED' named entity 'CLASSICAL' named entity 'ANTIBODIES' named entity 'TECHNOLOGIES' named entity 'IMMUNE' named entity 'RESEARCH' named entity 'RECOMBINANT ANTIBODY' named entity 'LONG' named entity 'PROTEIN ENGINEERING' named entity 'CHAPTER' named entity 'CRITICAL' named entity 'ALTERNATIVE' named entity 'ATTRACTIVE' named entity 'UNDERSTANDING' named entity 'COMPANIES' named entity 'OUR' named entity 'MOVED ' named entity 'DIRECT' named entity 'SPECIFICITY' named entity 'EFFICACY' named entity 'THEIR' named entity 'RAPIDLY' named entity 'attractive' named entity 'rapidly' named entity 'investigators' named entity 'inherent' named entity 'high affinity' named entity 'phage display' named entity 'antibody' named entity 'protein engineering' named entity 'polyclonal' named entity 'Affinity Reagents' named entity 'classical'

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